阿利苯多对大鼠的围产期毒性

doi:10.3969/j.issn.1004616x.2012.06.014

Carcinogenesis, Teratogenesis & Mutagenesis

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The toxic effects of Alibendol during perinatal period in rats

HUANG Feng-jiao，LI Yan，LI Jing，GONG Xia-shi，MENG Hong-ya，LI Ji-hong

Hubei Provincial Institute Co., Ltd. of Pharmaceutical Industry, Hubei Center for Safety Evaluation of Drug, Wuhan 430061, Hubei, China

Received:2011-10-13 Revised:2012-09-24 Online:2011-11-30 Published:2011-11-30
Contact: HUANG Feng-jiao，E-mail：huangfengjiao000@yahoo.con.cn
About author:黄凤娇 (1976- )，女，湖北省恩施市人，硕士，助理研究员，研究方向：药理毒理。E-mail：huangfengjiao000@yahoo.con.cn

Abstract

Abstract:

OBJECTIVE: To identify the toxic effects of Alibendol on the maternal rat in late trimester of pregnancy，the growth and development，and the abilities of learning and reproduction of the offsprings． METHODS：SD pregnant rats were given Alibendol orally from gestational day 15 to weaning day 21. The experimental groups received 50，100 and 200 mg/(kg·d) of Alibendol．The growth，development and reproductive capacity of pregnant rats and offsprings were recorded. RESULTS：There were no obviouse toxic effects on F0 rats．For the body weight of fetal rats(F1)，there was a significant increase in low-dose group compared with control group at birth， day 4 after birth and mature male (P＜0.05). However，a significant difference of fetal rats in ear path opening in low-dose group and pain threshold time in meddle-dose group compared with control group (P＜0.05) were observed too. But there was no dose-effect relationship. There were no differences between treated groups and control group in other indexes. CONCLUSION： Among the dose range used，Alibendol was safe to reproductive capability of female rats and growth of fetal rats．

Key words: Alibendol, rat, reproductive toxicity, fetus, growth, development

HUANG Feng-jiao，LI Yan，LI Jing，GONG Xia-shi，MENG Hong-ya，LI Ji-hong. The toxic effects of Alibendol during perinatal period in rats[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004616x.2012.06.014.

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The toxic effects of Alibendol during perinatal period in rats

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