三七花提取液对小鼠的致突变作用研究

doi:10.3969/j.issn.1004616x.2012.06.013

Carcinogenesis, Teratogenesis & Mutagenesis

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Study of the mutagenic action of notoginseng flower extract on mice

QIN Guang-he，LI Zi

Yunnan Center for Disease Control and Prevention, Kunming 650022, China

Received:2012-04-17 Revised:2012-09-20 Online:2011-11-30 Published:2011-11-30
Contact: QIN Guang-he,Tel：0871-3625173；E-mail：qgh513@yahoo.com.cn
About author:秦光和(1974- )，男，湖南通道人，主管技师，研究方向：卫生毒理学。Tel：0871-3625173；E-mail：qgh513@yahoo.com.cn

Abstract

Abstract:

OBJECTIVE: To study the mutagenic action of notoginseng flower extract on mice. METHODS：The mice were treated by oral gavages twice 24 hours apart with notoginseng flower extract of different doses (10 000，5 000，2 500 mg/kg). Animals were killed after 6 h of the last treatment，and then the micronucleus frequency (MNF) of polychromatic erythrocytes (PCE) in bone marrow were measured. In addition，at the above doses and groups another group of mice were treated by oral gavages once a day for 5 consecutive days. The mice were killed after 35 days of the initial treatment and the sperm deformity rate was observed. The two experiments also consisted of the negative control group (pure water) and positive control group (cyclophosphamide 40 mg/kg) at the same time. RESULTS：Every dosage group of notoginseng flower extract showed no mouse bone marrow micronucleus nor sperm abnormality effect. CONCLUSION： Under the present experimental conditions，notoginseng flower extract showed no mutagenic effect on mice.

Key words: notoginseng flower, mutation, polychromatic erythrocytes, micronucleus, sperm deformity

QIN Guang-he，LI Zi. Study of the mutagenic action of notoginseng flower extract on mice[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004616x.2012.06.013.

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Study of the mutagenic action of notoginseng flower extract on mice

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