[1] SIEGEL R L, MILLER K D, FUCHS H E, et al. Cancer statistics, 2021[J]. CA Cancer J Clin, 2021, 71(1):7-33. [2] CHANDRA A, PIUS C, NABEEL M, et al. Ovarian cancer:current status and strategies for improving therapeutic outcomes[J]. Cancer Med, 2019, 8(16):7018-7031. [3] XIA R L, XU M S, YANG J, et al. The role of Hedgehog and Notch signaling pathway in cancer[J]. Mol Biomed, 2022, 3(1):44. [4] DEXTER J S. The analysis of a case of continuous variation in Drosophila by a study of its linkage relations[J]. Am Nat, 1914, 48(576):712-758. [5] MORGAN T. The theory of the gene[J]. Am Nat, 1917, 51:513-544. [6] KANZ D, KONANTZ M, ALGHISI E, et al. Endothelial-to-hematopoietic transition:notch-ing vessels into blood[J]. Ann N Y Acad Sci, 2016, 1370(1):97-108. [7] HOPFER O, ZWAHLEN D, FEY M F, et al. The Notch pathway in ovarian carcinomas and adenomas[J]. Br J Cancer, 2005, 93(6):709-718. [8] CHOI J H, PARK J T, DAVIDSON B, et al. Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion[J]. Cancer Res, 2008, 68(14):5716-5723. [9] LIU Z Z, ZHU Y C, LI F F, et al. GATA1-regulated JAG1 promotes ovarian cancer progression by activating Notch signal pathway[J]. Protoplasma, 2020, 257(3):901-910. [10] JIA D Y, UNDERWOOD J, XU Q P, et al. NOTCH2/NOTCH3/DLL3/MAML1/ADAM17 signaling network is associated with ovarian cancer[J]. Oncol Lett, 2019, 17(6):4914-4920. [11] YANG J, XING H, LU D H, et al. Role of Jagged1/STAT3 signalling in platinum-resistant ovarian cancer[J]. J Cell Mol Med, 2019, 23(6):4005-4018. [12] WANG M Y, WU L Y, WANG L, et al. Down-regulation of Notch1 by gamma-secretase inhibition contributes to cell growth inhibition and apoptosis in ovarian cancer cells A2780[J]. Biochem Biophys Res Commun, 2010, 393(1):144-149. [13] DEFREITAS S, ROWE M, PACULIS L, et al. Integration of bioinformatics approaches and experimental validations to understand the role of Notch signaling in ovarian cancer[J]. J Vis Exp, 2020(155).doi:10.3791/60502. [14] PARK J T, SHIH I M, WANG T L. Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer[J]. Cancer Res, 2008, 68(21):8852-8860. [15] KANG H, JEONG J Y, SONG J Y, et al. Notch3-specific inhibition using siRNA knockdown or GSI sensitizes paclitaxel-resistant ovarian cancer cells[J]. Mol Carcinog, 2016, 55(7):1196-1209. [16] GAO M Q, CHOI Y P, KANG S, et al. CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells[J]. Oncogene, 2010, 29(18):2672-2680. [17] WANG M Y, WANG J, WANG L, et al. Notch1 expression correlates with tumor differentiation status in ovarian carcinoma[J]. Med Oncol, 2010, 27(4):1329-1335. [18] ALNIAIMI A N, DEMOREST-HAYES K, ALEXANDER V M, et al. Increased Notch1 expression is associated with poor overall survival in patients with ovarian cancer[J]. Int J Gynecol Cancer, 2015, 25(2):208-213. [19] YANG M R, ZHANG G D, WANG Y Y, et al. Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer[J]. Br J Cancer, 2020, 123(9):1404-1416. [20] KUHNERT F, CHEN G Y, COETZEE S, et al. Dll4 blockade in stromal cells mediates antitumor effects in preclinical models of ovarian cancer[J]. Cancer Res, 2015, 75(19):4086-4096. [21] ZHOU J S, JAIN S, AZAD A K, et al. Notch and TGFβ form a positive regulatory loop and regulate EMT in epithelial ovarian cancer cells[J]. Cell Signal, 2016, 28(8):838-849. [22] PARK J T, LI M, NAKAYAMA K, et al. Notch3 gene amplification in ovarian cancer[J]. Cancer Res, 2006, 66(12):6312-6318. [23] MCAULIFFE S M, MORGAN S L, WYANT G A, et al. Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy[J]. Proc Natl Acad Sci U S A, 2012, 109(43):E2939-E2948. [24] ISLAM S S, ABOUSSEKHRA A. Sequential combination of cisplatin with eugenol targets ovarian cancer stem cells through the Notch-Hes1 signalling pathway[J]. J Exp Clin Cancer Res, 2019, 38(1):382. [25] FENG Z Y, XU W D, ZHANG C G, et al. Inhibition of gamma-secretase in Notch1 signaling pathway as a novel treatment for ovarian cancer[J]. Oncotarget, 2017, 8(5):8215-8225. [26] ALLAM H, JOHNSON B P, ZHANG M, et al. The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer[J]. J Biol Chem, 2017, 292(39):16351-16359. [27] KIM L K, PARK S A, YANG Y, et al. LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial-mesenchymal transition[J]. Biosci Rep, 2021, 41(9):BSR20210565. [28] DRENZEK J G, SEILER N L, JASKULA-SZTUL R, et al. Xanthohumol decreases Notch1 expression and cell growth by cell cycle arrest and induction of apoptosis in epithelial ovarian cancer cell lines[J]. Gynecol Oncol, 2011, 122(2):396-401. |