实验室炎症相关指标的列线图对预测舌鳞状细胞癌患者手术预后的价值

doi:10.3969/j.issn.1004-616x.2023.05.007

Abstract

Abstract: OBJECTIVE: Tongue squamous cell carcinoma (TSCC) had a high rate of metastasis and postoperative recurrence. Our study objective was to use a nomogram model to provide prognosis of TSCC patients undergoing surgery. METHODS: From 2008 to 2019,a retrospective analysis was performed on 167 patients with TSCC who were treated in the Cancer Hospital Affiliated to Shantou University Medical College. Cox regression analysis was used to identify independent prognostic factors associated with the overall survival (OS) which was used to build a nomogram and to predict OS. The predictive accuracy of the model was evaluated by calibration curve, decision curve (DCA) and the concordance index (C-index). RESULTS: Results from the multivariate Cox regression and Kaplan-Meier survival analyses show that B-factor (BF), monocyte count,lymphocyte-monocyte ratio,and tumor lymph node metastasis (TNM) stage were independent prognostic factors,which were used to build the prognostic nomogram model. The C-index of the nomogram was 0.754[95%CI(0.672,0.835)],which was higher than that of the TNM stage 0.679[95%CI(0.602,0.755)]. The Akaike information criterion (AIC) and Bayesian information criterion (BIC) of the nomogram were 312.134 and 318.239,respectively. Both were lower than 319.163 and 320.689 for TNM stages alone,indicating that the nomogram has better goodness of fit for OS prediction. The calibration curves of the nomogram show good consistency between the predicted OS probabilities and the actual OS value of patients. In addition, timedependent C-index analysis and DCA results show that the prognostic nomogram model had good predictive accuracy and discriminability compared with TNM stage. CONCLUSION: A nomogram model based on clinicopathological features and preoperative inflammation-related indicators may be useful in predicting the prognosis of TSCC patients undergoing surgery.

Key words: tongue squamous cell carcinoma, inflammation?related indicators, surgery, nomogram, prognosis

CLC Number:

R730.3

WEI Laifeng, HONG Chaoqun, CHEN Liuyi, XU Yiwei, WU Fangcai. Prognostic value of nomogram of laboratory inflammation-related indicators in tongue squamous cell carcinoma patients with surgery[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(5): 366-373.

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Prognostic value of nomogram of laboratory inflammation-related indicators in tongue squamous cell carcinoma patients with surgery

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