Abstract: OBJECTIVE： To investigate relationships among neutrophil/lymphocyte ratios (NLR)， inflammation indices(SII)， tumor markers CEA， CA19-9， CA72-4 and the clinical stages of gastric cancer (GC)；and to develop a nomogram prediction model. METHODS：From January 2019 to May 2022， clinical data from 192 gastric cancer patients who were admitted to the General Surgery Department of the Second Affiliated Hospital of the Zhengzhou University were collected. The preoperative NLR，SII，albumin and serum CEA，CA19-9 and CA72-4 levels of early and advanced gastric cancer groups were determined. Differences in the collected data between the two groups of patients were analyzed. Then，the cut-off value for each test index was determined by the receiver working characteristic (ROC) curve. The nomogram of Logistic regression model was drawn to evaluate the diagnostic value of the markers alone and in combinations for preoperative gastric cancer stages. RESULTS：All preoperative NLR，SII，CEA，CA19-9，and CA72-4 levels were higher in the advanced gastric cancer group than in the early gastric cancer group (P<0.05). The ROC curve analysis showed that the area under the curve (AUC) of NLR，SII，CEA，CA19-9，CA72-4 alone were 0.817，0.792， 0.722， 0.724， and 0.761， respectively， and the best cut-off values were 2.09， 366.73， 2.18， 7.44， and 3.63，respectively. The AUC for each index was 0.944，the sensitivity was 89.3%，and the specificity was 89.2% . A nomogram prediction model including NLR，SII，CEA，CA19-9，CA72-4 and clinical stage was constructed. The internal validation consistency index (C index) was 0.915，and the correction curve suggested that the accuracy of the model was good. CONCLUSION： Preoperative NLR， SII， CEA， CA19-9， and CA72-4 were associated with clinical stages of gastric cancers. In addition，the nomogram model which was constructed based on preoperative NLR， SII， CEA， CA19-9， CA72-4 levels and clinical stage had good accuracy and clinical utility.

Key words: NLR, SII, gastric cancer, clinical stages, staging nomogram