Abstract: OBJECTIVE: To identify prognostic factors among patients with stage Ⅲ gastric cancers who underwent radical resections. METHODS: From January 2017 to April 2021，116 patients with stage Ⅲ gastric cancers who underwent surgery were selected. General data and preoperative clinical indicators were collected from these patients. Correlations between serum C-reactive protein (CRP)，programmed cell death ligand 1 (PD-L1)，angiopoietin-2 (Ang-2) and clinicopathological parameters were compared. The best cut-off value of serum index before operation was determined by receiver operating characteristic (ROC) curve. Survival conditions of the patients was analyzed by Kaplan-Meier method. Cox proportional hazard regression model was established for multi-factor analysis. The value of factors in predicting prognosis of gastric cancers was evaluated using the line chart model. RESULTS: There were significant differences in preoperative CRP，PD-L1 and Ang-2 levels in age，tumor diameter，vascular invasion，nerve invasion，depth of invasion，lymph node metastasis，lymph node metastasis and differentiation. The results of survival analyses showed that the patients with preoperative serum CRPl <19.53 mg/L，PD-L1 ≥42.80 pg/mL and Ang-2 <305.16 μg/L had longer survival times and higher 1-year survival rates. The results of Cox proportional hazard regression analyses showed that preoperative CRP，PD-L1，Ang-2，tumor diameter，vascular invasion，nerve invasion，depth of invasion，lymph node metastasis and degree of differentiation were independent predictors of prognosis in patients with gastric cancers (P<0.05). The C-index consistency index of the line chart prediction model was 0.863. The calibration curve test showed that the results were highly consistent with the actual occurrence probability. CONCLUSION: In patients with gastric cancers，preoperative serum CRP levels exceeded 19.53 mg/L，preoperative serum PD-L1 levels were lower than 42.80 pg/mL，preoperative serum Ang-2 levels exceeded 305.16 μg/L，tumor diameters exceeded 5 cm，vascular invasion，nerve invasion，depths of invasion were more than T3，and those lymph node metastasis and poor differentiation had better prognosis.-Detection of preoperative serum CRP，PD-L1，Ang-2 concentration，tumor diameter，vascular and nerve invasion，depth of invasion，lymph node metastasis，differentiation and other pathological indicators can be helpful for long-term prognosis of patients.

Key words: gastric cancer, C-reactive protein, programmed cell death-ligand 1, angiopoietin-2, prognosis