中国前列腺癌患者TMPRSS2::ETS融合基因发生率的meta分析

doi:10.3969/j.issn.1004-616x.2022.05.003

Abstract

Abstract: OBJECTIVE: To use meta-analysis for assessing the occurrence of TMPRSS2::ERG fusion gene in Chinese patients with prostate cancer.METHODS: A systematic search was conducted through PubMed,Web of Science,Google Scholar,China knowledge Resource Database (CNKI),Wanfang Medical online Database and VIP Database.The risk of bias was assessed using QUADAS-2 and a meta-analysis was performed using Stata12.0 and Review Manager 5.3 to evaluate the occurrence of TMPRSS2::ERG fusion gene in Chinese prostate cancer patients.RESULTS: A total of 16 articles were included.The incidence rate of TMPRSS2::ERG fusion gene in prostate cancer was 16.7%[95% CI (14.5%,18.8%)].Regarding the type of samples,biopsy specimens showed the incidence rate of fusion gene was 17.9%[95% CI (15.8%,20.1%)].When using immunohistochemistry (IHC) detection technology,the incidence rate of fusion gene was 16.6%[95% CI (13.0%,20.2%)].CONCLUSION: The occurrence of TMPRSS2::ERG fusion gene was low in Chinese prostate cancer patients,therefore,the TMPRSS2::ERG fusion gene cannot be used as a diagnostic marker for Chinese prostate cancer patients.

Key words: prostate cancer, TMPRSS2::ETS fusion gene, Chinese population, meta-analysis

CLC Number:

R596.2

ZHANG Jiawei, YUAN Qin, XU Xianrong, FANG Xuexian, CAO Yifei, YANG Jun. Occurrence of the TMPRSS2::ETS fusion gene in Chinese patients with prostate cancer: a meta-analysis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(5): 344-352.

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Occurrence of the TMPRSS2::ETS fusion gene in Chinese patients with prostate cancer: a meta-analysis

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