术前检查指标dNLR、SII、CRP/ALB对乳腺癌复发转移的预测价值

doi:10.3969/j.issn.1004-616x.2022.04.007

Abstract

Abstract: OBJECTIVE: To study predictive values of preoperative laboratory indexes[derived neutrophil to lymphocyte ratio (dNLR),systemic immune inflammatory index (SII),and C-reactive protein (CRP)/albumin (ALB)] on recurrences and metastases in breast cancer patients. METHODS: The patients who received surgical treatment and diagnosed with breast cancer by postoperative pathology in Sichuan Neijiang Second People's Hospital from April 2016 to April 2019 were selected as the research objects. Their clinical and pathological data, followed-up recurrences and metastases and disease-free survival times was collected. The Kaplan Meier curve of disease-free survival was drawn. Relationships between different clinicopathological data and disease-free survival were analyzed by log-rank test. Influencing factors of disease-free survival were analyzed by COX regression model. Predictive values of different indices on disease-free survival were analyzed using ROC curve. RESULTS: Log rank test of Kaplan-Meier curve of disease-free survival showed that the cumulative disease-free survival rates of breast patients with different tumor stage, lymph node metastasis, neutrophils to lymphocyte ratio,platelet to lymphocyte ratio,lymphocyte to monocyte ratio,dNLR,SII,and CRP/ALB were statistically different (log-rank χ²=12.020,5.332,3.923,4.948,15.340,22.970,5.496,all P< 0.05). COX regression model analyses showed that AJCC stage,dNLR,SII,CRP/ALB were the influencing factors of disease-free survival of breast cancer patients (P<0.05). ROC curve analyses showed that dNLR,SII and CRP/ALB alone had predictive values for disease free survival. Regression equations of dNLR,SII and CRP/ALB were obtained in the logistic model, which could be used as a combined index to predict disease-free survival of breast cancer patients. CONCLUSION: Laboratory indices dNLR,SII and CRP/ALB were related to postoperative recurrences and metastases of breast cancers. The combination of the three indices can provide a basis for prognosis evaluations.

Key words: breast cancer, recurrence, metastasis, prognosis, forecast

CLC Number:

R737.9

WANG Xujuan, LUO Yongxin, LI Chenqiang, WANG Rujin, ZHENG Tingting. Predictive values of preoperative laboratory indices dNLR, SII and CRP/ALB on recurrences and metastases in breast cancer patient[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(4): 284-288,323.

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Predictive values of preoperative laboratory indices dNLR, SII and CRP/ALB on recurrences and metastases in breast cancer patient

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