CD68巨噬细胞浸润对原发性食管小细胞癌预后的影响

doi:10.3969/j.issn.1004-616x.2022.04.006

Abstract

Abstract: OBJECTIVE: To investigate infiltrations of different subtypes of tumor-associated macrophages in primary esophageal small cell carcinomas (PESC),and their relationships with clinico-pathological parameters and prognosis. METHODS: Clinico-pathological data of PESC from January 2000 to December 2019 in Cancer Hospital of the Shantou University Medical College were analyzed retrospectively. Infiltrations of the CD68 and CD163 macrophages were evaluated by immunohistochemistry. The Chi-square and Fisher's exact tests were used to evaluate their relationships with the clinico-pathological indices. Furthermore,Kaplan-meier and Multivariate Cox regression were used to analyze prognosis for PESC. RESULTS: CD68- and CD163-stained macrophages were located in cytoplasmic or membrane of tumor cells. CD68 macrophage infiltrations,specifically,were correlated with tumor T stages (χ²=6.336,r=-0.303,P=0.012). However,the infiltrations showed no association with the other clinico-pathological variables. Kaplan-meier analyses showed that the pTNM stage, number of surgical lymph node dissection, N stage, adjuvant chemotherapy and infiltration were associated with overall survival (P<0.05). Multivariate Cox regression analyses showed that pTNM stage, the number of lymph node dissection and the infiltration were independent prognostic factors. High infiltrations were significantly associated with overall survival compared with low infiltrations (Hazard ratio=0.340, 95% confidence interval 0.179-0.645; P=0.001). CONCLUSION: High infiltration of CD68 macrophages,but not CD163,was an independent prognostic factor for patients with PESC. Patients with high infiltrations had significantly favorable prognoses than those with low infiltration of CD68 macrophages.

Key words: tumor-associated macrophage, primary esophageal small cell carcinoma, prognosis, CD68, CD163

CLC Number:

R735.1

ZHANG Yuling, LIU Ditian, CHEN Chunfa. Impact of CD68 macrophage infiltration on prognosis in primary small cell esophageal carcinoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(4): 279-283.

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Impact of CD68 macrophage infiltration on prognosis in primary small cell esophageal carcinoma

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