深圳市某区低学龄儿童血脂异常与血清中铅和镉浓度的关系

doi:10.3969/j.issn.1004-616x.2021.06.011

Abstract

Abstract: OBJECTIVE: The aims of this study were to explore correlations between dyslipidemia and serum concentrations of lead (Pb) and cadmium (Cd) in low school-aged children in a district of Shenzhen,and to provide evidence for prevention and treatment of children with dyslipidemia. METHODS: Cluster samplings were used to select all first-grade primary school children in Shenzhen,and blood biochemical tests and lifestyle questionnaires were conducted among them. Children with dyslipidemia were selected as the experimental group (n=663),and healthy ones (n=663) as the control group using 1:1 matching according to age ±0.5 years old and gender. Serum concentrations of Pb and Cd among the children were tested using the inductively coupled plasma mass spectrometry (ICP-MS) method. RESULTS: Serum concentrations of Pb and Cd in children with dyslipidemia (133.08 μg/L and 0.45 μg/L,respectively) were higher than those in controls (84.19 μg/L and 0.29 μg/L,respectively,P<0.05). Conditional Logistic regression analyses show that,after adjustment for covariates,serum Pb[OR=2.52,95%CI (1.66,3.83)] and Cd[OR=4.31,95%CI (2.73,6.82)] were associated with an increased risk of dyslipidemia in children in a dose-response relationship (P_trend<0.01). CONCLUSION: Dyslipidemia was associated with increased serum Pb and Cd concentrations in low school-aged children in a district of Shenzhen. The results indicate that we should pay more attention to concentrations of heavy metals in their low school-aged children in order to prevent chronic diseases and to promote their health.

Key words: heavy metals, lead, cadmium, children, dyslipidemia

CLC Number:

R179

LIU Ruiguo, CHEN Xiaoli, YOU Yingbin, LI Shufan, ZHANG Qingying. Relationships between dyslipidemia and serum levels of lead and cadmium in low school-aged children in a district of Shenzhen[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 461-465.

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Relationships between dyslipidemia and serum levels of lead and cadmium in low school-aged children in a district of Shenzhen

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