全自动DNA图像分析系统在胰腺恶性肿瘤诊断中的价值

doi:10.3969/j.issn.1004-616x.2021.06.009

Abstract

Abstract: OBJECTIVE: To evaluate values of automatic DNA image analyses (DNA-ICM) in diagnosis of pancreatic malignant tumors. METHODS: Patients with suspected pancreatic malignant tumor who underwent endoscopic ultrasonics guided fine needle puncture were recruited for our study. Collected samples were tested by conventional cytology and DNA-ICM. Diagnostic values of cytology,DNA-ICM and their combination were analyzed using histopathological diagnosis as the standard reference to clinical follow-up data. RESULTS: Among the 108 patients,sensitivity,specificity,positive predictive value,negative predictive value and accuracy of conventional cytological diagnosis were higher than those of DNA-ICM (93.1% vs 90.8%,95.2% vs 90.5%,98.8% vs 97.5%,76.9% vs 70.4%,93.5% vs 90.7%). However,there was no statistical significance between them (P>0.05). The combined diagnosis indexes for the two methods were 95.4%,90.5%,97.6%,82.6%,94.4%,respectively. Sensitivity,negative predictive value and accuracy of the combined diagnosis were higher than those of single diagnosis,but the differences were not statistically significant (P>0.05). CONCLUSION: DNA-ICM combined cytological diagnosis has great application value,and DNA-ICM showed good auxiliary diagnostic values for pancreatic cytology diagnosis.

Key words: DNA-ICM, EUS-FNA, pancreatic, malignancy

CLC Number:

R734.2

WANG Rui, WANG Heng, WU Juan, JI Xiaokun, GUO Xiao, MA Yang, DU Yun. Values of automatic DNA image analyses in diagnosis of pancreatic malignant tumors[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 451-454.

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Values of automatic DNA image analyses in diagnosis of pancreatic malignant tumors

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