血清谷胱甘肽过氧化物酶与晚期非小细胞肺癌患者临床病理指标及预后的相关性

doi:10.3969/j.issn.1004-616x.2021.04.008

Abstract

Abstract: OBJECTIVE: To investigate correlations between glutathione peroxidase (GSH-PX) in serum and clinicopathological indicators,curative effect of combined radio-with chemotherapy and prognosis of advanced non-small cell lung cancers (NSCLC). METHODS: In 2018,174 newly diagnosed advanced NSCLC patients (before anticancer therapy) from the Department of Oncology,Affiliated Hospital of Hebei University of Engineering and 80 healthy controls were recruited for our investigation. Expressions of GPX3 in different tumors were analyzed via the data of on-line. Activities of GSH-PX in serum from peripheral blood samples were detected via 5',5-dithio-bis-nitrobenzoic acid (DTNB). Activities of GSH-PX were compared between the advanced NSCLC and the control groups. In addition,relationships between activities of GSH-PX and clinicopathological indicators,curative effect of combined radio-with chemotherapy and prognosis of advanced non-small cell lung cancer were analyzed. RESULTS: Data from the gene expression profiling interactive analysis (GEPIA) show that expressions of GPX3 in 33 kinds of tumors (lung squamous cell carcinoma and lung adenocarcinoma) were significantly lower than that in the controls (P<0.05). Results from DTNB show that GSH-PX activities in serums of patients were significantly lower than that in the controls (P<0.05) and were irrelevant to the age,gender and pathological patterns of patients (P>0.05). However GSH-PX activities were negatively related to smoking histories and tumor sizes (r=-0.295、0.228,all P<0.05),and positively related to KPS scores and pathological grades (r=0.295、0.228,P all <0.05). There was no difference in GSH-PX activities between patients with effective and failed treatments (P>0.05). Overall survivals in the high activities group was higher than those in the low activities group (P<0.05),and they were positively related (r=0.238,P=0.000). CONCLUSION: GSH-PX activities in serum of patients with advanced NSCLC were significantly reduced,and the activities were related to smoking histories,KPS scores,tumor sizes,pathological grades and overall survivals. Therefore,GSH-PX activities were involved in the development and prognosis of NSCLC.

Key words: non-small cell lung cancer, glutathione peroxidase, clinicopathologic indicators, crutive effect, overall survival, prognosis

CLC Number:

R734.2

LIU Xiaoxia, LI Weixia, LI Zhijia, SU Zhenjun, DUAN Xiaohui, HAN Weiwen, WANG Yunxiao, HE Xiaolei, Lu Linlin, JIA Jinhai. Correlations between glutathione peroxidase in serum and clinicopathological outcomes of advanced non-small cell lung cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(4): 286-290,295.

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Correlations between glutathione peroxidase in serum and clinicopathological outcomes of advanced non-small cell lung cancer

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