食管鳞癌中SERPINE1 mRNA的表达及其临床意义

doi:10.3969/j.issn.1004-616x.2021.04.001

Abstract

Abstract: OBJECTIVE: To investigate expression status and clinical relevance of SERPINE1 mRNA in esophageal squamous cell carcinoma (ESCC) tissues. METHODS: Expressions of SERPINE1 mRNA were determined using tissue microarrays and RNAscope in situ hybridizations in surgically-resected tumor tissues and adjacent normal epithelia from 236 ESCC patients. Relationships between the mRNA expression and clinicopathological characteristics as well as prognosis were analyzed. RESULTS: Increased expression of SERPINE1 mRNA was observed in 23.7% (56/236) of the tumor tissues. However,there was no expression of SERPINE1 mRNA in normal tissues which were adjacent to the carcinomas. The increased expressions were positively correlated with genders,histological grades,T stages and clinical stages (r=7.939,6.618,10.939,6.671,respectively;each P<0.05). Kaplan-Meier survival curves show that patients with high expressions of SERPINE1 mRNA had shorter survival times than those with low expressions (P<0.05). Cox multiple regression analyses indicate that SERPINE1 mRNA expression was an independent prognosis factor in ESCC. CONCLUSION: SERPINE1 mRNA was expressed highly in ESCC tissues. Our data indicate that the expression may serve as a molecular biomarker for predicting poor prognosis of ESCC patients.

Key words: esophageal squamous cell carcinoma, RNA in situ hybridization, SERPINE1, biomarker

CLC Number:

R735.1

CHANG Chen, YANG Liyan, CAI Hongqing, YUAN Qing, HAO Jiajie, WANG Mingrong. Expressions and clinical implications of SERPINE1 mRNA in esophageal squamous carcinoma tissues[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(4): 245-249.

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Expressions and clinical implications of SERPINE1 mRNA in esophageal squamous carcinoma tissues

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