1号染色体平衡易位及其断裂点位置与人精液质量的相关性分析

doi:10.3969/j.issn.1004-616x.2020.05.011

Abstract

Abstract: OBJECTIVE: To investigate impact of chromosome 1 translocation and locations of its breakpoints on semen quality in male carriers. METHODS: Lymphocytes in peripheral blood of patients with male infertility were cultured and G-banding technique was used for karyotype analysis. Semen examinations were performed according to WHO laboratory manual for the examination and processing of human semen. RESULTS: Twenty-nine male patients with infertility were diagnosed as carriers with chromosome 1 balanced translocations. Abnormal semen parameters were observed in most of patients (25/29,86%). The different degrees of abnormal semen quality were detected in the patients with the different translocation breakpoints. CONCLUSION: The chromosome 1 balanced translocations were associated with reduced semen quality. The degree of impact was closely related to the locations of the translocation breakpoints. Some molecular investigations are needed to better understand the impact of chromosome translocations on reproductive fitness.

Key words: chromosome 1, balanced translocation, breakpoint, male infertility

CLC Number:

R394

LIU Jing, HAN Tingting, MENG Xiangqian, HUANG Tingting, WEN Zina, ZHOU Lingyi, LIAO Xue, LI Lingxiao, ZHANG Xinyue, ZHONG Ying, HUANG Jihua. Impact of chromosome 1 translocation and its breakpoint on semen quality in male carriers[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 391-394.

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Impact of chromosome 1 translocation and its breakpoint on semen quality in male carriers

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