CREB在食管鳞癌组织中的表达及其临床意义

doi:10.3969/j.issn.1004-616x.2020.05.010

Abstract

Abstract: OBJECTIVE: To study the expression of cAMP-response element binding protein (CREB), in esophageal squamous cell carcinoma (ESCC) tissues,and its relationship with clinical characteristics and prognosis of the patients. METHODS: Samples of tumor tissues and paraplastic tissues were collected from 60 cases of the ESCC patients from January to December,2010. Expression of CREB in both tissues and their relationships with the clinical feathers of the patients were analysed by using Western blotting and Immunohistochemical assays. RESULTS: The tumor tissues showed significantly increased expression of CREB protein,compared with the paraplastic tissues (P < 0.01). Among patients,those with higher CREB expression tended to have large tumors,later clinical stages,higher lymph node metastasis and shorter five-year overall survival rate with higher cumulative recurrence rate (P < 0.05). CONCLUSION: The ESCC tissues showed significantly elevated expression of CREB protein. Furthermore,the patients with higher CREB expression in tumor tissues frequently had worse clinical outcomes and poorer prognoses. Therefore,CREB has the potential to be an ESCC-associated tumor marker.

Key words: CREB, ESCC, clinical progression, prognosis

CLC Number:

R735.1

GUO Xiujuan, DU Yanyan, YAN Xi, ZHAO Xuetao, HAN Lina, WU Yipeng, WANG Xuexiao, MA Ming. Expression and clinical significance of CREB in esophageal squamous cell carcinoma tissues[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 387-390,394.

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Expression and clinical significance of CREB in esophageal squamous cell carcinoma tissues

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