miR-429和Bmi-1 mRNA在肺癌组织中的表达及其临床意义

doi:10.3969/j.issn.1004-616x.2020.05.007

Abstract

Abstract: OBJECTIVE: To study the clinical significance of the expression of miR-429 and Bmi-1 in lung carcinoma (LC) tissues. METHODS: Samples of tumor tissues and paraplastic tissues were collected from 60 LC patients,January to December,2013. Expression of miR-429 and Bmi-1 mRNA in both tissues were detected by the quantitative real-time PCR (qPCR) assay. In addition,their relationships with clinical features and prognosis of the patients were analysed. RESULTS: The tumor tissues showed significantly decreased expression of miR-429 and increased expression of Bmi-1,compared with the paraplastic tissues (P < 0.01). Among the patients,those with lower expression of miR-429 and higher expression of Bmi-1 in their tumor tissues tended to have larger tumors,later clinical stages,more prone to lymph node metastasis and shorter survival time. CONCLUSION: The results show that the LC patients with lower miR-429 expression and/or higher Bmi-1 expression in tumour tissues frequently had worse clinical outcomes and poorer prognoses.

Key words: miR-429, Bmi-1, lung carcinoma, prognosis, clinical significance

CLC Number:

R734.2

SHAO Junguo, JIAO Wenjing, WANG Xuexiao, ZHANG Jinyan, MA Ming. Clinical significance of mi-429 and Bmi-1 mRNA expressions in lung carcinoma tissues[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 369-373.

References

[1] CHEN W, ZHENG R, BAADE P D, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2):115-132.
[2] XIAO Y, YAN W, LU L, et al. p38/p53/miR-200a-3p feedback loop promotes oxidative stress-mediated liver cell death[J]. Cell Cycle, 2015, 14(10):1548-1558.
[3] YANG X X, SANG M X, ZHU S C, et al. Radiosensitization of esophageal carcinoma cells by the silencing of BMI-1[J]. Oncol Rep, 2016, 35(6):3669-3678.
[4] 马鸣, 栾亦然, 白函瑜, 等. 微RNA-429通过抑制Bmi-1表达提高食管鳞癌细胞的化疗敏感性[J]. 肿瘤, 2019, 39(12):993-1003.
[5] 马鸣, 魏思思, 武一鹏, 等. Mda-7/IL-24与C-myb在Burkitt淋巴瘤中的表达及其相关性研究[J]. 免疫学杂志, 2017, 33(8):691-696.
[6] ZHOU X, MEN X, ZHAO R, et al. miR-200c inhibits TGF-β-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer[J]. Cancer Gene Ther, 2018, 25(3):68-76.
[7] TAMAGAWA S, BEDER L B, HOTOMI M, et al. Role of miR-200c/miR-141 in the regulation of epithelial-mesenchymal transition and migration in head and neck squamous cell carcinoma[J]. Int J Mol Med, 2014, 33(4):879-886.
[8] FAN L, WANG J, CAO Q, et al. Aberrant miR-1246 expression promotes radioresistance in non-small cell lung cancer:a potential prognostic biomarker and radiotherapy sensitization target[J]. Am J Cancer Res, 2020, 10(1):314-335.
[9] LI J, XU X, WEI C, et al. Long noncoding RNA NORAD regulates lung cancer cell proliferation, apoptosis, migration, and invasion by the miR-30a-5p/ADAM19 axis[J]. Int J Clin Exp Pathol, 2020, 13(1):1-13.
[10] MA M, ZHAO L, SUN G, et al. Mda-7/IL-24 enhances sensitivity of B cell lymphoma to chemotherapy drugs[J]. Oncol Rep, 2016, 35(5):3122-3130.
[11] YANG X X, MA M, SANG M X, et al. BMI-1 suppression increases the radiosensitivity of oesophageal carcinoma via the PI3K/Akt signaling pathway[J]. Oncol Rep, 2018, 39(2):667-678.
[12] GLOUSHANKOVA N A. Changes in regulation of cell-cell adhesion during tumor transformation[J]. Biochemistry (Mosc), 2008, 73(7):742-750.
[13] 栾亦然, 刘丽源, 皎龙, 等. MiR-429及Bmi-1 mRNA在弥漫性大B细胞淋巴瘤中的表达及其临床意义[J]. 癌变·畸变·突变, 2020, 32(3):177-181.
[14] HUR K, TOIYAMA Y, TAKAHASHI M, et al. microRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis[J]. Gut, 2013, 62(9):1315-1326.

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Clinical significance of mi-429 and Bmi-1 mRNA expressions in lung carcinoma tissues

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