CD10蛋白在结直肠癌组织中的表达及其临床意义

doi:10.3969/j.issn.1004-616x.2020.05.003

Abstract

Abstract: OBJECTIVE: The aim of this study was to investigate associations between expression of CD10 protein and clinicopathological characteristics in colorectal cancer patients. METHODS: 78 cases of colorectal cancer tissue samples and 22 cases of neighboring noncancer colorectal tissue samples were collected from colorectal cancer patients. In addition,expression of CD10 protein in tissue samples was determined using rapid immunohistochemical EliVision method. Relationships between the expression intensity and clinicopathological characteristics of colorectal cancer were analyzed by the Chi Square test. RESULTS: There was no expression of CD10 protein in 22 normal colorectal tissue samples. The positive rate of CD10 expression was significantly different in colorectal cancer tissue samples and in neighboring noncancer colorectal tissue samples:46.2%(36/78) and 0,(P < 0.01). The expression intensity of CD10 protein in cancer tissues was not clearly related to gender,age,tumor location,differentiation degree and depth of invasion (P > 0.05) but was higher in the more advanced stages than in the early stages (P=0.033),and was also associated with lymph node metastasis (P=0.023) and vessel invasion (P=0.004). On the other hand,the data show no significant correlation between the expression ratio of CD10 protein and clinicopathological characteristics of colorectal cancer (P > 0.05). CONCLUSION: CD10 protein was highly expressed in colorectal cancer tissues and the expression intensity was associated with clinical stage,lymph node metastasis and vessel invasion,which suggests that CD10 protein may play roles in promoting the development,invasion and metastasis of colorectal cancer.

Key words: colorectal cancer, CD10, neutral endopeptidase, immunohistochemistry

CLC Number:

R735.3+4

YANG Xiuyuan, PAN Yuelong. Expression of CD10 protein in colorectal carcinomas and its clinical significance[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 344-349.

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Expression of CD10 protein in colorectal carcinomas and its clinical significance

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