Abstract: OBJECTIVE: To explore the effect of Danzhijiangtang capsule on pathological changes of heart and kidney in diabetic rats. METHODS: 70 male SD rats,randomly selected 10 as normal group,the average feed,the rest 4 weeks rats a high-fat feed,intraperitoneal injection of chain urea with streptozotocin (STZ) 34 mg/kg copy type Ⅱ diabetic rat model,building is not successful rats intraperitoneal injection of STZ injection 25 mg/kg. The model rats were divided into four groups of 10 rats per group according to blood glucose and volume:model group,high-dose Danzhijiangtang capsule group[1.08 g/(kg·d)],low-dose Danzhijiangtang capsule group[0.54 g/(kg·d)],and pionlitazone group[10 mg/(kg·d)]. The normal group and the model group were given the same volume of normal saline. Blood glucose,blood lipid,renal function (BUN,Scr,mAlb,urinary protein) were detected by automatic biochemical analyzer. Cardiac tissues were stained with HE and MASSON,and renal tissues were stained with HE,MASSON and glycogen PAS. Pathological changes of tissues were investigated. RESULTS: Compared with the normal group,the model group rats showed decreased volume,significantly increased food intake and water intake,blood sugar,blood lipid and renal function index (P < 0.01). In addition,they showed visible infiltration of heart inflammatory cells,increased myocardial fibrosis,changes in kidney baumann's capsule structure,and significantly increased cytoplasmic matrix and the degree of fibrosis. After 6 weeks of administration and compared with the model group,the volume of pioglitazone group and the high-dose Danzhijiangtang capsule group significantly increased,the food intake and water intake decreased,and the indexes of blood glucose,blood lipid and kidney function decreased (P < 0.05,P < 0.01). In addition,the pathological changes of heart and kidney slowed down. Although the indexes of blood glucose,blood lipid and renal function of rats in the low dose danzhu hypoglycemic capsule group decreased,there was no significant difference from the TC level (P > 0.05). However,there were statistical differences between the levels of HbAlc,TG,TC and mAlb and those in the pyrrolitazone group (P < 0.05,P < 0.01). CONCLUSION: Administration of either high or low dose Danzhijiangtang capsules effectively reduced blood glucose and lipid levels in rats,relieved the symptoms of polyphagia and polydipsia,and reduced the damage of hyperglycemia in myocardial and renal tissues of rats.

Key words: Danzhijiangtang capsule, diabetes mellitus, heart, kidney, pathological changes