NFKBIA基因多态性、饮食习惯及其交互作用与胃癌易感性的关系

doi:10.3969/j.issn.1004-616x.2020.03.008

Abstract

Abstract: OBJECTIVE: To analyze relationships between NFKBIA gene polymorphism,eating habits and susceptibility to gastric cancer. METHODS: 1:1 matched case-control study was carried out with 587 newly-diagnosed primary gastric patients and 587 controls matched by sex and age in the Fujian Xianyou hospital from April 2013 to June 2017. The data of general information and eating habits were collected by a self-made questionnaire. The Sequenom MassARRAY SNP detection method was used to detect the genotype of NFKBIA gene rs696 locus. Condition logistic regression was used to analyze the effects of eating habits and genotypes on risk of gastric cancer. Forked analysis,logistic regression model and Excel table compiled by Andersson were used to evaluate the interactive effects of NFKBIA polymorphism and eating habits. RESULTS: Fast eating,irregular meals,high salt diet and often pickle intakes were the risk factors of gastric cancer. OR(95%CI) were 1.53(1.20,1.95),1.55(1.16,2.08),1.51(1.17,1.94),2.78(2.01,3.85) respectively. The NFKBIA rs696 locus AG genotype,AA genotype and dominant model (AG+AA) increased the risk of gastric cardia cancer. In addition,the interaction effects were found on rs696 AA genotype with high salt diet and pickle intakes. The interactive effects were also found on the rs696 dominant model (AG+AA) with fast eating,high salt diet and often intake pickles. CONSLUSION:Bad eating habit was a risk factor of gastric cancer. The NFKBIA rs696 AA genotype,the dominant model (AG+AA) increased the risk of gastric-cardia cancer and had an interaction effect with eating habits.

Key words: gastric cancer, NFKBIA polymorphism, inflammation signaling pathway, eating habits, interaction effects

CLC Number:

R181

LI Dan, LIU Baoying, YU Mingming, ZHUANG Hailin, JIE Jinhua, WU Hanmei. NFKBIA polymorphism, eating habits and susceptibility to gastric cancer: a case-control study[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(3): 198-202.

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NFKBIA polymorphism, eating habits and susceptibility to gastric cancer: a case-control study

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