数据挖掘分析SLC7A11在食管癌中的表达及通过P53/ROS通路调节细胞铁死亡的意义

doi:10.3969/j.issn.1004-616x.2020.02.008

Abstract

Abstract: OBJECTIVE: To explore the expression and function of solute carrier family 7 member 11 (SLC7A11) in esophagus cancer (ESCA) and its prognostic value in patients. METHODS: Differences in expression of SLC7A11 in ESCA tissues and normal esophageal tissues were analyzed using the Oncomine and GEPIA databases. GeneMANIA database was used to construct the protein-protein interaction network (PPI) which is related to SLC7A11, and functional annotation was carried out to analyze its common enrichment functions. KEGG Pathway database was used to analyze the signaling pathways involved. Kaplan-Meier curve was drawn using the R2 gene analysis visualization platform to study the association of SLC7A11 expression and overall survival (OS) of ESCA patients. RESULTS: Based on the Oncomine and GEPIA databases,the mRNA expression levels of SLC7A11 in ESCA tissues were significantly higher than that in normal tissues,the prognosis of patients in the high-expression group was worse,and their differences were statistically significant (P < 0.05). SLC7A11 interacts with 20 proteins including SLC3A2, BSG, ASNS, PHGDH, TERT and CD44, and they were enriched in amino acid transport, modified amino acid transmembrane transporter activity, leukocyte migration,peptide antigen binding and other biological functions. SLC7A11 was involved in regulation of the ferroptosis (hsa04216) signaling pathway. CONCLUSION: SLC7A11 was up-regulated in ESCA significantly, indicative of poor prognosis, involved in ferroptosis through the P53 and ROS metabolic pathways. Therefore,SLC7A11 can be considered to be biomarkers for early diagnosis,treatment and prognosis of patients with ESCA.

Key words: esophagus cancer, SLC7A11, data mining, ferroptosis

CLC Number:

R735.1

XIONG Yingyou, YANG Li, FANG Chengxiang, WU Qian, ZHANG Wei, ZHAO Yi, WEN Jing. Data mining analysis of SLC7A11 expression in esophageal cancer and its involvement in regulating ferroptosis through the P53/ROS Metabolic Pathway[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(2): 126-131.

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Data mining analysis of SLC7A11 expression in esophageal cancer and its involvement in regulating ferroptosis through the P53/ROS Metabolic Pathway

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