深圳和太原PM2.5样品致突变作用研究

doi:10.3969/j.issn.1004-616x.2019.06.013

Abstract

Abstract: OBJECTIVE: The Ames tests were used to investigate the mutagenicity of PM_2.5 samples which were collected from Shenzhen and Taiyuan. METHODS: The histidine-deficient Salmonella typhimurium strains TA97,TA98,TA100,TA102 and TA1535 were used. From the collected samples,four doses of PM_2.5 (40,100,200,and 400 μg per dish),a negative control and a positive control were tested. Each test group was treated with S9 or without S9. RESULTS: After treatment with PM_2.5 samples from Shenzhen,there were significant differences in mutagenicity (P < 0.01) between +S9 and -S9 groups in TA98,TA100 and TA102.Similar results were observed with PM_2.5 samples from Taiyuan in TA97,TA98 and TA100. These results indicated that the PM_2.5 samples from Shenzhen and Taiyuan contained mutagenic chemicals which did not cause mutation in TA1535. CONCLUSION: Overall,our results indicate that PM_2.5 samples from Shenzhen and Taiyuan contained directly and indirectly acting mutagens.

Key words: PM_2.5, Ames test, spontaneous mutation colonies, mutagenicity

CLC Number:

R122.7

ZHENG Kai, WANG Bingyu, XU Xinyun, GENG Hong, HUANG Haiyan, LIU Wei, LONG Dingxin. Mutagenicity of PM_2.5 samples from Shenzhen and Taiyuan[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(6): 483-487.

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Mutagenicity of PM_2.5 samples from Shenzhen and Taiyuan

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Mutagenicity of PM2.5 samples from Shenzhen and Taiyuan

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Mutagenicity of PM_2.5 samples from Shenzhen and Taiyuan