JAK2基因突变与慢性髓系白血病易感性的meta分析

doi:10.3969/j.issn.1004-616x.2019.03.011

Abstract

Abstract: OBJECTIVE:To investigate the association between JAK2 gene mutation and development of chronic myeloid leukemia (CML). METHODS: A systematic literature searches of CNKI, VIP, Wanfang, PubMed,Web of Science and CBM databases were conducted in September 2018. The identified publications were screened for inclusion and exclusion criteria by two researchers independently. Data were extracted from selected papers and evaluated for quality using a modified NOS score. Meta-analyses were performed by using the Stata 11.0 and RevMan 5.3 software. RESULTS:A total of 15 articles were selected which included 1 684 cases and 104 mutations (JAK2V617F mutation is characterized by a G to T transversion at nucleotide 1 849 in exon 12 or exon 14 of the gene). Meta-analyses show that the mutation rate of JAK2 in CML patients was 0.08[95%CI (0.05,0.11)]. Subgroup analyses show that the main reason for heterogeneity of whether Ph and JAK2 mutations involved different regions and exon mutation site. CONCLUSION:The JAK2 exon 12 and 14 mutations and mutant JAKV617F were associated with the development of CML.

Key words: JAK2, gene mutation, chronic myeloid leukemia, meta-analysis

CLC Number:

R557+.3

YANG Jinru, QIN Lulu, ZHU Yongfei. Meta analysis on association between JAK2 gene mutation and susceptibility to chronic myeloid leukemia[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(3): 231-237.

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Meta analysis on association between JAK2 gene mutation and susceptibility to chronic myeloid leukemia

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