弥漫大B细胞淋巴瘤患者血清IL-24及IL-6浓度检测的临床意义

doi:10.3969/j.issn.1004-616x.2019.03.010

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2019, Vol. 31 ›› Issue (3): 227-230.doi: 10.3969/j.issn.1004-616x.2019.03.010

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Clinical values of serum IL-24 and IL-6 concentrations for patients with diffuse large B-cell lymphoma

MA Ming¹, JIAO Wenjing¹, WANG Yanhai², YAN Xi¹, ZHANG Chao¹, ZHANG Jinyan¹

1. The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011;
2. Hebei Military Outpatient Department, Shijiazhuang 050011, Hebei, China

Received:2018-09-26 Revised:2018-12-19 Online:2019-05-31 Published:2019-05-31

Abstract

Abstract: OBJECTIVE:To investigate the significance of IL-24 and IL-6 concentrations in serum of patients with Diffuse large B-cell lymphoma (DLBCL). METHODS:Concentrations of serum IL-24 and IL-6 were detected using the ELISA assay. The relationship between the concentrations and the clinicopathological parameters in 43 cases of DLBCL patients was analyzed. RESULTS:Compared with the control patients,the concentrations of IL-24 and IL-6:(58.32 ±11.81) and (24.63 ±7.73) μg/mL, respectively, and the IL-24 concentration:(42.18 ±8.48) μg/mL in the DLBCL patients were significantly lower, whereas the IL-6 concentration:(45.29±12.71) μg/mL was significantly higher (P<0.01). Furthermore,the concentrations of IL-24 was significantly lower,while the IL-6 was higher in the serum of the patients who had bone marrow invasion than those without the invasion (P<0.01). The similar results were also shown in the patients with the high IPI scores (P<0.01). These findings suggest that the low IL-24 and high IL-6 concentrations may be predictors for poor clinical status and prognosis of DLBCL patients. CONCLUSION:Detection of the serum IL-24 and IL-6 concentrations may be useful as auxiliary diagnosis for improved clinical therapy in DLBCL.

Key words: diffuse large B-cell lymphoma, IL-24, IL-6, serum tumor marker

CLC Number:

R825.5

MA Ming, JIAO Wenjing, WANG Yanhai, YAN Xi, ZHANG Chao, ZHANG Jinyan. Clinical values of serum IL-24 and IL-6 concentrations for patients with diffuse large B-cell lymphoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(3): 227-230.

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Clinical values of serum IL-24 and IL-6 concentrations for patients with diffuse large B-cell lymphoma

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