miR-146a多态性与非小细胞肺癌易感性的研究

doi:10.3969/j.issn.1004-616x.2019.03.009

Abstract

Abstract: OBJECTIVE:To study the relationship between miR-146a rs2910164 G/C gene polymorphism and non-small cell lung cancer in the Han population. METHODS:rs2910164 genotypes in 198 patients with non-small cell lung cancers and 218 control subjects were detected by PCR-restriction fragment length polymorphism (PCR-RFLP). Logistic regression analysis was used. RESULTS: Compared with the control group,logistic regression analyses show that the genotype carrying the C allele was significantly associated with increased risk of non-small cell lung cancer[dominant model OR=5.04, 95% CI (4.72, 5.39), P<0.01; recessive model OR=2.75, 95% CI was (2.57, 2.94), P<0.01]. Further analyses show that there was no statistical relationship between the rs2910164 gene polymorphism and clinical features (gradation, stage, metastasis) (P>0.05) and there was no interaction between the rs2910164 gene polymorphism and smoking (P> 0.05). CONCLUSION:Our results show that the genotype carrying the miR-146a rs2910164 C allele may be associated with genetic susceptibility to non-small cell lung cancer.

Key words: single nucleotide polymorphisms, genetic susceptibility, non-small cell lung cancer, miR-146a

CLC Number:

R734.2

YING Wei, WANG Xingyuan, JIANG Bo, ZHOU Wei. Association between polymorphisms in the miR-146a and susceptibility to non-small cell lung cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(3): 222-226.

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Association between polymorphisms in the miR-146a and susceptibility to non-small cell lung cancer

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