DNA甲基转移酶3B-149C>T多态性与致癌风险相关性的Meta分析

doi:10.3969/j.issn.1004-616x.2019.02.003

Abstract

Abstract: OBJECTIVE:To assess the associations between polymorphism of DNA methyltransferase 3B-149C > T (DNMT3B-149C > T) and cancer risk.METHODS:We evaluated and extracted the relevant literatures published from 1990 to 2017 based on Newcastle-Ottawa Scale (NOS).All genotype models of DNMT3B-149C > T were compared,including CC and TT,CT and TT,CC+CT and TT,and their distillations in case and control groups were comprehensively analyzed.Q-test and I2 value were used to analyze the heterogeneity among the studies.Begg and Egger regressions were used to verify the evaluation of publication bias,and Review Manager 5.0 and STATA version 12.0 software were used for Meta-analysis.The correlation between polymorphism of DNMT3B-149C > T and cancer risk was calculated by using the odds ratio (OR) and 95% confidence interval (95% CI).RESULTS:7 612 cancer cases and 9 679 healthy controls in the literature were analyzed.According to subgroup analysis of different cancer types,the DNMT3B-149C>T polymorphism was associated with lung cancer[OR=1.51,95%CI(1.08,2.12),P=0.02].CONCLUSION:DNMT3B-149C > T polymorphism may be a susceptibility factor for lung cancer.

Key words: DNA methyltransferase 3B, polymorphism, cancer, meta-analysis, lung cancer

CLC Number:

R730.2

WU Wen, LI Ping, ZUO Ran, ZENG Qingbo, WU Desheng, XIE Ni, LONG Dingxin, YUAN Jianhui. Correlation between polymorphism of DNA methyltransferase 3B-149C>T and cancer risk:a meta-analysis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(2): 102-110.

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Correlation between polymorphism of DNA methyltransferase 3B-149C>T and cancer risk:a meta-analysis

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