Carcinogenesis, Teratogenesis & Mutagenesis ›› 2019, Vol. 31 ›› Issue (1): 73-78.doi: 10.3969/j.issn.1004-616x.2019.01.014
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2018-08-27
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2018-10-23
Online:
2019-01-31
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2019-01-31
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[1] EICHHORN P J,CREYGHTON M P,BERNARDS R. Protein phosphatase 2A regulatory subunits and cancer[J]. Biochim Biophys Acta,2009,1795(1):1-15. [2] VIRSHUP D M,SHENOLIKAR S. From promiscuity to precision:protein phosphatases get a makeover[J]. Mol Cell,2009,33(5):537-545. [3] WLODARCHAK N,XING Y. PP2A as a master regulator of the cell cycle[J]. Crit Rev Biochem Mol Biol,2016,51(3):162-184. [4] LIU W H,CHOU W M,CHANG L S. p38 MAPK/PP2Acalpha/TTP pathway on the connection of TNF-alpha and caspases activation on hydroquinone-induced apoptosis[J]. Carcinogenesis,2013,34(4):818-827. [5] TOMASELLA A,BLANGY A,BRANCOLINI C. A receptor-interacting protein 1(RIP1)-independent necrotic death under the control of protein phosphatase PP2A that involves the reorganization of actin cytoskeleton and the action of cofilin-1[J]. J Biol Chem,2014,289(37):25699-25710. [6] TEIXEIRA V,MEDEIROS T C,VILACA R,et al. Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells[J]. Cell Signal,2015,27(9):1840-1849. [7] STOTLAND A,GOTTLIEB R A. Mitochondrial quality control:Easy come,easy go[J]. Biochim Biophys Acta,2015,1853(10):2802-2811. [8] SCARPULLA R C. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network[J]. Biochim Biophys Acta,2011,1813(7):1269-1278. [9] DU K,RAMACHANDRAN A,MCGILL M R,et al. Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity[J]. Food Chem Toxicol,2017,108(Sup A):339-350. [10] SHUKLA K,SONOWAL H,SAXENA A,et al. Aldose reductase inhibitor,fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells[J]. Cancer Lett,2017,411:57-63. [11] RICE A C,KEENEY P M,ALGARZAE N K,et al. Mitochondrial DNA copy numbers in pyramidal neurons are decreased and mitochondrial biogenesis transcriptome signaling is disrupted in Alzheimer's disease hippocampi[J]. J Alzheimers Dis,2014,40(2):319-330. [12] BERNSMEIER C,DUONG F H,CHRISTEN V,et al. Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C[J]. J Hepatol,2008,49(3):429-440. [13] WENZ T. Regulation of mitochondrial biogenesis and PGC-1α under cellular stress[J]. Mitochondrion,2013,13(2):134-142. [14] TAN Z,LUO X,XIAO L,et al. The role of PGC1alpha in cancer metabolism and its therapeutic implications[J]. Mol Cancer Ther,2016,15(5):774-782. [15] BERNSMEIER C,CALABRESE D,HEIM M H,et al. Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1alpha and dephosphorylation of FoxO1[J]. J Viral Hepat,2014,21(1):9-18. [16] LI J,GENG X Y,CONG X L. PGC-1alpha ameliorates angiotensin Ⅱ-induced eNOS dysfunction in human aortic endothelial cells[J]. Vascul Pharmacol,2016,83:90-97. [17] LIU L,HUANG Z,CHEN J,et al. Protein phosphatase 2A activation mechanism contributes to JS-K induced caspase-dependent apoptosis in human hepatocellular carcinoma cells[J]. J Exp Clin Cancer Res,2018,37(1):142. [18] DORN G W,VEGA R B,KELLY D P. Mitochondrial biogenesis and dynamics in the developing and diseased heart[J]. Genes Dev,2015,29(19):1981-1991. [19] DICKEY A S,STRACK S. PKA/AKAP1 and PP2A/Bbeta2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics[J]. J Neurosci,2011,31(44):15716-15726. [20] GARIPLER G,MUTLU N,LACK N A,et al. Deletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiae[J]. Proc Natl Acad Sci USA,2014,111(4):1473-1478. [21] YOULE R J,VAN DER BLIEK A M. Mitochondrial fission,fusion,and stress[J]. Science,2012,337(6098):1062-1065. [22] AREA-GOMEZ E,DE GROOF A,BONILLA E,et al. A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease[J]. Cell Death Dis,2018,9(3):335. [23] MELBER A,HAYNES C M. UPR(mt) regulation and output:a stress response mediated by mitochondrial-nuclear communication[J]. Cell Res,2018,28(3):281-295. [24] LI H,TANG Z,CHU P,et al. Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo:Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways[J]. Free Radic Biol Med,2018,120:228-238. [25] JIANG M Y,HAN Z D,LI W,et al. Mitochondrion-associated protein peroxiredoxin 3 promotes benign prostatic hyperplasia through autophagy suppression and pyroptosis activation[J]. Oncotarget,2017,8(46):80295-80302. [26] NEITEMEIER S,JELINEK A,LAINO V,et al. BID links ferroptosis to mitochondrial cell death pathways[J]. Redox Biol,2017,12:558-570. [27] MURPHY E,ARDEHALI H,BALABAN R S,et al. Mitochondrial function,biology,and role in disease:A scientific statement from the American Heart Association[J]. Circ Res,2016,118(12):1960-1991. [28] WILLIAMS M,CAINO M C. Mitochondrial dynamics in type 2 diabetes and cancer[J]. Front Endocrinol (Lausanne),2018,9:211. [29] ISHIHARA N,OTERA H,OKA T,et al. Regulation and physiologic functions of GTPases in mitochondrial fusion and fission in mammals[J]. Antioxid Redox Signal,2013,19(4):389-399. [30] CHEN H,CHAN D C. Emerging functions of mammalian mitochondrial fusion and fission[J]. Hum Mol Genet,2005,14(Sup 2):R283-R289. [31] CHO B,CHO H M,KIM H J,et al. CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation[J]. Exp Mol Med,2014,46:e105. [32] CHEROK E,XU S,LI S,et al. Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics[J]. Mol Biol Cell,2017,28(3):396-410. [33] CHOI S G,KIM H,JEONG E I,et al. SUMO-modified FADD recruits cytosolic Drp1 and Caspase-10 to mitochondria for regulated necrosis[J]. Mol Cell Biol,2017,37:e00254-16 [34] LAVIE J,SERRAT R,BELLANCE N,et al. Mitochondrial morphology and cellular distribution are altered in SPG31 patients and are linked to DRP1 hyperphosphorylation[J]. Hum Mol Genet,2017,26(4):674-685. [35] KANG Y J,BANG B R,HAN K H,et al. Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling[J]. Nat Commun,2015,6:8371. [36] DAGDA R K,ZAUCHA J A,WADZINSKI B E,et al. A developmentally regulated,neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis[J]. J Biol Chem,2003,278(27):24976-24985. [37] ZHANG Y,CHEN X,GUEYDAN C,et al. Plasma membrane changes during programmed cell deaths[J]. Cell Res,2018,28(1):9-21. [38] YU J,NAGASU H,MURAKAMI T,et al. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy[J]. Proc Natl Acad Sci USA,2014,111(43):15514-15519. [39] STUTZ A,KOLBE C C,STAHL R,et al. NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain[J]. J Exp Med,2017,214(6):1725-1736. [40] MERRILL R A,SLUPE A M,STRACK S. N-terminal phosphorylation of protein phosphatase 2A/Bbeta2 regulates translocation to mitochondria,dynamin-related protein 1 dephosphorylation,and neuronal survival[J]. FEBS J,2013,280(2):662-673. [41] RUVOLO P P,CLARK W,MUMBY M,et al. A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function[J]. J Biol Chem,2002,277(25):22847-22852. [42] CHO M H,KIM D H,CHOI J E,et al. Increased phosphorylation of dynamin-related protein 1 and mitochondrial fission in okadaic acid-treated neurons[J]. Brain Res,2012,1454:100-110. [43] PLACIDO A I,PEREIRA C M,CORREIRA S C,et al. Phosphatase 2A inhibition affects endoplasmic reticulum and mitochondria homeostasis via cytoskeletal alterations in brain endothelial cells[J]. Mol Neurobiol,2017,54(1):154-168. [44] LIN M T,BEAL M F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases[J]. Nature,2006,443(7113):787-795. [45] CAITO S W,ASCHNER M. Mitochondrial redox dysfunction and environmental exposures[J]. Antioxid Redox Signal,2015,23(6):578-595. [46] CHEN Y,ZHANG H,ZHOU H J,et al. Mitochondrial redox signaling and tumor progression[J]. Cancers (Basel),2016,8(4):40. [47] MARTINA J A,PUERTOLLANO R. Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress[J]. J Biol Chem,2018,293(32):12525-12534. [48] XU C,WANG X,ZHU Y,et al. Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A[J]. Neuropharmacology,2016,105:270-284. [49] XIE Z Z,SHI M M,XIE L,et al. Sulfhydration of p66Shc at cysteine59 mediates the antioxidant effect of hydrogen sulfide[J]. Antioxid Redox Signal,2014,21(18):2531-2542. [50] SHIMURA T,SASATANI M,KAMIYA K,et al. Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in low dose irradiated human fibroblasts[J]. Oncotarget,2016,7(3):3559-3570. [51] WILSON A,YAKOVLEV V A. Cells redox environment modulates BRCA1 expression and DNA homologous recombination repair[J]. Free Radic Biol Med,2016,101:190-201. [52] KIM M O,CHOE M H,YOON Y N,et al. Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells[J]. Biochem Pharmacol,2017,144:78-89. [53] RIZZA S,CARDACI S,MONTAGNA C,et al. S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy[J]. Proc Natl Acad Sci USA,2018,115(15):e3388-e3397. [54] SCHUCK S,GALLAGHER C M,WALTER P. ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery[J]. J Cell Sci,2014,127(Sup 18):4078-4088. [55] MAAN M,PETERS J M,DUTTA M,et al. Lipid metabolism and lipophagy in cancer[J]. Biochem Biophys Res Commun,2018,504(3):582-589. [56] CHEN Y,HENSON E S,XIAO W,et al. Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia[J]. Autophagy,2016,12(6):1029-1046. [57] ZHOU H,LUO W,ZENG C,et al. PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines[J]. Oncotarget,2017,8(46):80770-80789. [58] SPRINGER M Z,MACLEOD K F. In Brief:Mitophagy:mechanisms and role in human disease[J]. J Pathol,2016,240(3):253-255. [59] OH C K,SULTAN A,PLATZER J,et al. S-nitrosylation of PINK1 attenuates PINK1/Parkin-dependent mitophagy in hiPSC-based Parkinson's disease models[J]. Cell Rep,2017,21(8):2171-2182. [60] SIMPSON C L,ROMPOLAS P,HOLZBAUR E L. The autophagy receptor NIX drives injury-induced mitophagy in keratinocytes and promotes mitochondrial fragmentation during epidermal differentiation[J]. J Invest Dermatol,2017,137(5):S70. [61] ZHANG W,SIRAJ S,ZHANG R,et al. Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury[J]. Autophagy,2017,13(6):1080-1081. [62] GEORGAKOPOULOS N D,WELLS G,CAMPANELLA M. The pharmacological regulation of cellular mitophagy[J]. Nat Chem Biol,2017,13(2):136-146. [63] KABI A,MCDONALD C. Protein phosphatase 2A has positive and negative roles in autophagy[M]//Autophagy:Cancer,other pathologies,inflammation,immunity,infection,and aging. 2014:211-225. [64] RICE M,DAGDA R,STRACK S. Role of protein phosphatase 2A in modulating autophagy and mitophagy (LB220)[C]. FASEB J,2014,28(Sup 1):LB220. [65] QI Z,YANG W,LIU Y,et al. Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model[J]. Neurochem Int,2011,59(5):572-581. [66] FURUKAWA K,FUKUDA T,YAMASHITA S I,et al. The PP2A-like protein phosphatase Ppg1 and the Far complex cooperatively counteract CK2-mediated phosphorylation of Atg32 to inhibit mitophagy[J]. Cell Rep,2018,23(12):3579-3590. [67] SATOH K,YACHIDA S,SUGIMOTO M,et al. Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC[J]. Proc Natl Acad Sci USA,2017,114(37):7697-7706. |
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