纳米TiO2对子代大鼠免疫系统的毒性研究

doi:10.3969/j.issn.1004-616x.2019.01.013

Abstract

Abstract: OBJECTIVE:To explore the effects from exposure to nano-TiO₂ on the immune system of offspring of rats. METHODS:SD rats were divided into nano-TiO₂ and control groups with 30 females and 15 males in each group. Exposed groups were given nano-TiO₂ by gastric filling method at the doses of 250 mg/kg,and the control group was given equal volume of NaCl. The exposure was continued for 2 weeks before mating,and throughout pregnancy and lactation. Offspring were infused nano-TiO₂ or NaCl into stomach from weaning to execution. Immune function of offspring was observed on PND56. Observation indexes included organ coefficients of liver,spleen and thymus,and splenic and paneth lymphocyte typing and antibody-producing cell assay. RUSULTS:Organ coefficients of spleen in the nano-TiO₂ treated female rats group were significantly higher than that of the control group (P < 0.05). Organ coefficients of liver in nano-TiO₂ treated male rats group were significantly lower than that of the control group (P < 0.05). However,no abnormalities were found in histopathological examinations. No differences were observed on lymphocyte typing and antibody-producing cell assays between the nano-TiO₂ and the control groups (P > 0.05). CONCLUSION:The result suggests that,under the present experimental conditions,nano-TiO₂ has no effect on the immune system of offspring of rats.

Key words: nano-TiO₂, offspring rats, immunotoxicity, safety evaluation

CLC Number:

R994.6

LING Min, YANG Mingjing, LIANG Jie, CHEN Dongya, ZHANG Wei, BIAN Qian. Effects from exposure to nano-TiO₂ on the immune system of offspring of rats[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(1): 69-72.

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Effects from exposure to nano-TiO₂ on the immune system of offspring of rats

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Effects from exposure to nano-TiO2 on the immune system of offspring of rats

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Effects from exposure to nano-TiO₂ on the immune system of offspring of rats