Abstract: OBJECTIVE: This experiment mainly studied the toxicological effect of p-hydroxylcinnamal-dehyde(CMSP) extracted from the Cochinchina momordica seeds (CMS),on mice and provided a basis for clinical use of this drug. METHODS: 60 Kunming mice (4-6 weeks old) were randomly divided into three groups:control,200 mg/kg treatment and 400 mg/kg treatment groups. CMSP was administered by intraperitoneal injection. The general behavior,routine blood test,clinical biochemical test and teratospermia of the mice were evaluated. Furthermore,the pathologic changes of the vital organs were detected by immunohistochemical assay. Finally,the micronucleus formation in bone marrow cells was determined. RESULTS: There were no observed abnormal activities,blood test and teratospermia in CMSP treated-mice during the periods. However,the higher ALT and AST concentrations in serum were observed in the mice treated with 400 mg/kg CMSP. There were no abnormal changes of renal function,myocardial enzyme spectrum and pathologic changes of the vital organs. Moreover,there was no increase of micronucleus rate in bone marrow cells of treated mice. CONCLUSION: In our experiment,CMSP may have little toxic and side effects,so it may be considered for use in clinical treatments. However,it is also necessary to fully consider its possible toxicity to liver functions.

Key words: Cochinchina momordica, p-hydroxylcinnamaldehyde, toxicity effect, tumor, clinical treatment