儿童原发性激素敏感型肾病综合征与ACE基因多态性关系的meta分析

doi:10.3969/j.issn.1004-616x.2018.06.006

Abstract

Abstract: OBJECTIVE: To assess the relation of idiopathic steroid-sensitive nephrotic syndrome (SSNS) and ACE gene polymorphism in children. METHODS: To search from the database of PubMed,Cochrane Library,EMBASE,Science Citation Index,Wiley Online Library and Google Scholar,and obtained literatures according to the selection criteria,extracted relevant data and performed statistical analysis by Review Manager 5.1. RESULTS: A total of 10 publications including 1 617 subjects were screened out (524 SSNS children and 1 093 normal people). In the SSNS children,the frequency of D allele,DD genotype and Ⅱ genotype were higher than that in controls but the difference was not statistically significant. CONCLUSION: Our data did not show a polymorphism in the ACE gene was related to idiopathic SSNS.

Key words: angiotensin converting enzyme, gene polymorphism, pediatric, steroid-sensitive, nephritic syndrome, meta-analysis

CLC Number:

R363.1

XU Shizhang, XIE Minjuan. Relation between ACE gene polymorphism and pediatric idiopathic steroid-sensitive nephrotic syndrome: a meta-analysis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(6): 447-451.

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Relation between ACE gene polymorphism and pediatric idiopathic steroid-sensitive nephrotic syndrome: a meta-analysis

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