啤酒抗冷混浊硅基吸附剂对SD大鼠的胚胎毒性和致畸毒性

doi:10.3969/j.issn.1004-616x.2018.05.014

Abstract

Abstract: OBJECTIVE:To investigate embryo toxicity and teratogenicity of a silicone adsorbent for cold turbidity of beer on rats. METHODS:SD rats during pregnancy were given intragastric administration of silicon-based sorbent at 0.83,1.67 and 3.33 g/kg,respectively. After continuous administration of 10 d,growth of pregnant rats, embryonic development,fetal appearance,visceral deformities,and skeletal deformities were monitored. RESULTS:There was no significant difference in the observation indexes between pregnant rats and fetal rats in each dose group and the negative control group (all P > 0.05). CONCLUSION:The silicon sorbent did not show reproductive toxicity nor teratogenic effects in SD rats.

Key words: nano material, silicon sorbents, embryo toxicity, teratogenicity, rat

CLC Number:

R394.6
Q355

ZHAO Kangtao, WANG Qinghong, LIN Jian. Teratogenic investigation of a silicon adsorbent for cold turbidity of beer on SD rats[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(5): 400-402,406.

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Teratogenic investigation of a silicon adsorbent for cold turbidity of beer on SD rats

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