Notch信号通路相关蛋白在腺性膀胱炎和膀胱癌中的表达与意义

doi:10.3969/j.issn.1004-616x.2018.05.009

Abstract

Abstract: OBJECTIVE:To investigate the role of Notch signaling pathway in the development of cystitis glandularis (CG) and bladder urothelial cell carcinoma(BUC). METHODS:Expression of Notch1 and Hes1 protein were assessed by immunohistochemistry in bladder sections of 16 normal bladders and 26 CG samples from 50 patients with BUC. The relationship between CG and BUC,and the pathological grade and clinical stages of BUC were evaluated. RUSULTS:Notch1 was observed in normal bladder,CG samples and BUC samples,and the positive rates were 65.38% (17/26),70% (30/50) and 25% (4/16),respectively. The positive rates of Hes1 in CG,BUC and normal bladder tissues were 65.38% (17/26),76% (38/50) and 18.75% (3/13),respectively. Expressions of Notch1 and Hes1 in BUC and CG samples were significantly higher than that in normal bladder samples (P < 0.05) and increased with the pathological grades (P < 0.05). However,there was no significant difference (P > 0.05) in their expression in BUC and CG samples. CONCLUSION:Our study shows that Notch1 and Hes1 expressions were associated closely with the occurrence and pathological grade of BUC,as well as the occurrence and development of CG. Notch pathway might influence CG for the development of bladder cancer. Therefore,the expression may be used as a biomarker for diagnostic indices and for treatment option of CG.

Key words: cystitis glandularis, bladder cancer, Notch1, Hes1, immunohistochemistry

CLC Number:

R737.14

HUANG Zhuangcheng, WANG Honghao, SHEN Peilin, LIN Ming'en, HE Xuejun. Expression and clinical significance of Notch signalingrelated proteins in cystitis glandularis and bladder cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(5): 374-377,383.

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Expression and clinical significance of Notch signalingrelated proteins in cystitis glandularis and bladder cancer

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