Mda-7/IL-24和C-myb在弥漫大B细胞淋巴瘤中的表达及其临床意义

doi:10.3969/j.issn.1004-616x.2018.04.010

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2018, Vol. 30 ›› Issue (4): 297-301.doi: 10.3969/j.issn.1004-616x.2018.04.010

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Clinical significance of Mda-7/IL-24 and C-myb expression in diffuse large B-cell lymphoma

MA Ming¹, ZHAO Riyang², WU Hao², BAI Hanyu², ZHANG Cong², ZHAO Lianmei², YANG Xingxiao³, LIU Lihua⁴, SHAN Baoen²

1. Clinical Laboratory of the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011;
2. Research Centre of the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011;
3. Department of Infection Management of the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011;
4. Tumor Immunotherapy Department of the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China

Received:2017-08-09 Revised:2018-03-10 Online:2018-07-30 Published:2018-07-30

Abstract

Abstract: OBJECTIVE: This study aimed to investigate the clinical significance in expression of Mda-7/IL-24 and C-myb in diffuse large B-cell lymphoma (DLBCL) tissues. METHODS: Expression of Mda-7/IL-24 and C-myb in 72 tissues from DLBCL patients and 36 from normal lymphonodus tissues were assayed by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry. The relationship of Mda-7/IL-24 and C-myb expression and age,sex,clinical stage,bone marrow infiltration or not,Ecog scores,IPI index and survival was analyzed,and survival curves were prepared. RESULTS: The results show that compared with normal lymphonodus tissues,expression of Mda-7/IL-24 mRNA was higher,whereas expression of C-myb mRNA was lower. The expression of Mda-7/IL-24 mRNA was negatively correlated with C-myb (r=-0.43,P < 0.01). Low expression of Mda-7/IL-24 or high expression of C-myb were positively correlated with malignant grade,bone morrow metastases,IPI scores and shorter survival period (all P < 0.05). CONCLUSION: In summary,there was a negative correlation between Mda-7/IL-24 and C-myb expression in DLBCL tissues. The low expression of Mda-7/IL-24 and high expression of C-myb could be used as predictors for poor clinical conditions and prognosis of DLBCL.

Key words: Mda-7/IL-24, C-myb, diffuse large B-cell lymphoma, prognosis analysis

CLC Number:

R734.2

MA Ming, ZHAO Riyang, WU Hao, BAI Hanyu, ZHANG Cong, ZHAO Lianmei, YANG Xingxiao, LIU Lihua, SHAN Baoen. Clinical significance of Mda-7/IL-24 and C-myb expression in diffuse large B-cell lymphoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(4): 297-301.

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Clinical significance of Mda-7/IL-24 and C-myb expression in diffuse large B-cell lymphoma

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