RNF2和PCNA在食管鳞状细胞癌中的表达及临床意义

doi:10.3969/j.issn.1004-616x.2018.04.002

Abstract

Abstract: OBJECTIVE: To evaluate expression of ring finger protein 2(RNF2) and proliferating cell nuclear antigen(PCNA) in tumor tissue of patients with esophageal squamous cancer cells and their clinial significance. METHODS: By using immunohistochemical method,the expression of RNF2 and PCNA in tumor tissues and the tissues adjacent to tumors were detected in 64 cases of esophageal squamous cell cancer and in 30 cases of tissues adjacent to tumors. Relationships between their expression,and clinical pathology and prognosis were analyzed. The relationship between positive expression of RNF2 and postoperative 5-year survival rates of patients with esophageal cancers was also explored. RESULTS: RNF2 and PCNA proteins showed high expression in the tumor tissues. The positive expression rate of RNF2 was 54.69%(35/64) in the tumor tissues and 30.00%(9/30) in the adjacent tissues. The difference was statistically significant (χ²=5.000,P < 0.05). The positive expression rate of PCNA was 60.94%(39/64) in the tumor tissues and 46.67%(14/30) in the adjacent tissues. The difference was statistically significant (χ²=6.237,P < 0.05). The expressions of RNF2 and PCNA were closely related to the tumor size,TNM stage and lymph node metastasis (P < 0.05). However,no correlations were observed between the expression of RNF2 and other clinical features such as patient age,gender,and histological grade (P > 0.05). Among the esophageal cancer group,PCNA protein expression was significantly and positively correlated with RNF2 protein expression (r=0.494,P < 0.01). In addition,the survival time of patients with RNF2 positive expression was shorter(P < 0.01). CONCLUSION: RNF2 and PCNA expressions were found to be closely related and they also showed synergistic effects in the development of esophageal cancer.

Key words: esophageal cancer, RNF2, PCNA, immunohistochemistry

CLC Number:

R730.2

YANG Xingxiao, ZOU Naiyi, LI Qiaofang, ZHANG Xueyuan, SONG Heng, LIU Zhikun, MA Ming, SHAN Baoen, ZHU Shuchai. Significance in expression of RNF2 and PCNA proteins in esophageal squamous cancer cells[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(4): 254-257.

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Significance in expression of RNF2 and PCNA proteins in esophageal squamous cancer cells

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