邻苯二甲酸二辛酯亚慢性暴露对SD大鼠血细胞的影响

doi:10.3969/j.issn.1004-616x.2018.02.012

Abstract

Abstract: OBJECTIVE: To observe toxicological effects in blood cells in rats after treatment with different doses (0,5,50,500,2 500 mg/kg) DEHP. METHODS: Rats were divided into control and four treatment groups. The treatment groups were exposed to four concentrations of DEHP (5,50,500 and 2 500 mg/kg) for 90 days. At the end of the exposure,whole blood samples were taken to measure the changes of various types of blood cells. RESULTS: Compared with the control group,the leukocyte parameters for the 2 500 mg/kg dose groups were:eosinophils decreased significantly (P < 0.01),the total number of white rats significantly decreased (P < 0.05). Lymphocytes in 500 and 2 500 mg/kg groups were significantly increased (P < 0.05). In the erythrocyte parameters,the total number of red blood cells,hemoglobin (HGB) and hematocrit (HCT) in the 2 500 mg/kg group were significantly decreased (P < 0.01) while the levels of hemoglobin (HGB) in 500 and 2 500 mg (P < 0.05 or P < 0.05). Mean hemoglobin content (MCH) in 500 and 2 500 mg/kg groups decreased significantly (P < 0.05 or P < 0.01). The measured hemoglobin concentration (CHCM) decreased significantly (P < 0.05 or P < 0.01). On the other hand,DEHP had little effect on platelet parameters. CONCLUSION: DEHP exposure affected blood cells of rats under certain dosages.

Key words: DEHP, rat, leukocyte, erythrocyte, platelet

CLC Number:

R994.6

REN Xuedan, LI Nuo, LÜ Zhongming, WANG Minsheng. Toxicity to blood cells of SD rats from sub-chronic exposure to DEHP[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 140-143,149.

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Toxicity to blood cells of SD rats from sub-chronic exposure to DEHP

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