舌鳞状细胞癌组织中硫氧还蛋白和硫氧还蛋白还原酶-1的表达及其意义

doi:10.3969/j.issn.1004-616x.2018.02.002

Abstract

Abstract: OBJECTIVE: To study the expression and clinical significance of thioredoxin (Trx) and thioredoxin reductase-1 (TrxR1) in tongue squamous cell carcinoma. METHODS: Twenty-eight cases of tongue squamous cell carcinoma and 10 cases of normal epithelial tissues were collected. Expression levels of Trx and TrxR1 in two tissues were detected by the SP immunohistochemical three-step method. The relationship between their expression and clinicopathological features was analyzed. RESULTS: The expression levels of Trx and TrxR1 in tongue squamous cell carcinoma tissues were significantly higher than those in adjacent normal epithelial tissues. Trx IOD values in cancer tissues and adjacent normal tissues were (2.84±0.34)×10⁸ and (3.91±3.00)×10⁷,respectively (P < 0.01). TrxR1 IOD was (1.88±0.29)×10⁸ and (0.69±0.32)×10⁷ (P < 0.05). Trx and TrxR1 protein expression levels were between tumor size and differentiation;the differences in expression were statistically significant (P < 0.05). The expression levels of Trx and TrxR1 were moderately correlated (r=0.504,P < 0.05),and the high and low expression groups of Trx and TrxR1 were expressed. The difference in survival was statistically significant (P < 0.05). CONCLUSION: Thioredoxin and its reductase-1 can possibly be targets of drug therapy for tongue squamous cell carcinoma and important clinical indicators for early diagnosis and tumor screening.

Key words: tongue squamous cell carcinoma, thioredoxin, thioredoxin reductase-1, immunohistochemistry

CLC Number:

R780.2

LI Yang, XING Long, MOHAMMED H, MA Xiaolong, XIE Fuqiang, FENG Zhenghu, CHE Yinfu. Clinicopathological significance of expression of thioredoxin and its reductase-1 in tongue squamous cell carcinoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 87-91.

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Clinicopathological significance of expression of thioredoxin and its reductase-1 in tongue squamous cell carcinoma

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