[1] ROGAKOU E P,PILCH D R,ORR A H,et al. DNA double stranded breaks induce histone H2AX phosphorylation on serine 139[J]. J Biol Chem,1998,273(10):5858-5868.[2] BEKKER-JENSEN S,MAILAND N. Assembly and function of DNA double-strand break repair foci in mammalian cells[J]. DNA Repair (Amst),2010,9(12):1219-1228.[3] BOURTON E C,PLOWMAN P N,SMITH D,et al. Prolonged expression of the γ-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment[J]. Int J Cancer,2011,129:2928-2934.[4] FERNANDEZ-CAPETILLO O,LEE A,NUSSENZWEIG M, et al. H2AX:The histone guardian of the genome[J]. DNA Repair (Amst),2004,3:959-967.[5] BANÁTH J P,OLIVE P L. Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks[J]. Cancer Res,2003,63:4347-4350.[6] LI ZHENHONG,SUN BIN,REBECCA A,et al. Dose-response modeling of etoposide-induced DNA damage response[J]. Toxicol Sci,2014,137(2):371-384.[7] 李俊英,张士猛,周平坤. H2AX磷酸化与去磷酸化的分子机制及其对DNA损伤修复反应的调节作用[J]. 军事医学,2013,37(3):227-230.[8] SMART D J,AHMEDI K P,HARVEY J S,et al. Genotoxicity screening via the γH2AX by flow assay[J]. Mut Res,2011,715(1/2):25-31.[9] STEVEN M B,DEREK T B,JEFFREY C B,et al. Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach[J]. Environ Mol Mutagen, 2016,39(3):171-189.[10] KIRKLAND D,PFUHLER S,TWEATS D,et al. How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests:Report of an ECVAM Workshop[J]. Mut Res,2007, 628(1):31-55.[11] KIRKLAND D,AARDEMA M,HENDERSON L,et al. Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogensⅠ. sensitivity,specificity and relative predictivity[J]. Mut Res, 2005,584(1/2):1-256.[12] FOWLER P,SMITH K,YOUNG J,et al. Reduction of misleading (‘false’) positive results in mammalian cell genotoxicity assaysⅠ. choice of cell type[J]. Mut Res,2012, 742(1/2):1-25.[13] MÜLLER L. 4. 3 In-vitro genotoxicity tests to detect carcinogenicity:a systematic review[J]. Hum Exp Toxicol, 2009,28(2/3):131-133. |