Abstract: OBJECTIVE:To determine genotype-specific distribution of human papillomavirus (HPV) in women and to identify its relationship with cervical carcinoma in Chaoshan population. METHODS:Data from 30 000 women who were subjected to cervical HPV DNA testing were retrospectively evaluated in a hospital-based study. A total of 8 739 women,who had both HPV typing and pathological examination,were investigated. RESULTS:Overall,30.00% (9 000/30 000) of women were HPV positive,the frequency of HPV infection was 58.29% (5 094/8 739) in women with cervical cytological abnormalities,and the infection rate for patients with chronic cervicitis was 40.00% (1 088/2 720),patients with CIN I was 53.59%(1 396/2 605),patients with CIN was Ⅱ/Ⅲ 71.61% (1 647/2 300) and patients with cervical carcinoma was 86.45%(963/1 114). HPV 16 (14.02%) was the most common type for all cervical cytological abnormalities,followed by 18 type 6.28%(549),33 type 5.23%(457),58 type 4.46%(390) and 52 type 3.71% (324),while the more common HPV 16 type in cervical carcinoma with the highest infection (49.92%) was in women aged over 60. CONCLUSION:Our data indicate a relatively high prevalence of HPV 16,52,33,58 and 18 in women,their positive association with cervical cytological abnormalities. Specifically,the HPV 16 was the most common subtype among senior women with cervical carcinoma.

Key words: Chaoshan area, human papilloma virus, genotype, cervical carcinoma