外周血白细胞端粒相对长度与噪声性听力损失的相关性研究

doi:10.3969/j.issn.1004-616x.2017.03.012

Abstract

Abstract: OBJECTIVE:To study the correlation between telomere length of peripheral blood leukocytes and noise-induced hearing loss. METHODS:In a factory that produced computer shells,all posts that had noise intensity L_{EX,8 h} ≥ 85 dB(A),as determined by SV104IS wireless noise intensity detector,were selected. Questionnaires were used for collecting general and occupational information from workers and real-time polymerase chain reaction was used to detect telomere length of their peripheral blood leukocytes. Ordinal ploytomous logistic regression was used for analyzing the correlation between telomere length and noise-induced hearing loss. RESULTS:The average noise intensity among L_{EX,8 h} of overproof posts in the factory was (91.30±3.22) dB(A). This study recruited 127 noise-exposed workers consisting of 43 normal hearing workers (33.86%),75 abnormal high-frequency hearing loss workers (59.06%),9 abnormal speech-frequency hearing loss accompanied with abnormal high-frequency hearing loss (7.09%). Statistical significance was found in relative telomere length between different levels of noise-induced hearing loss (P < 0.05). It was revealed that noise intensity,age,gender and relative telomere length were factors related to noise-induced hearing loss (P < 0.05). CONCLUSION:Relative telomere length of peripheral blood leukocytes can potentially be used as a biomarker of susceptibility for noise-induced hearing loss.

Key words: peripheral blood leukocyte, telomere, relative length, noise-induced hearing loss

CLC Number:

R135.8

LIU Xinxia, LU Yao, LIU Haozhong, HE Yun. Correlation between telomere length of peripheral blood leukocytes and noise-induced hearing loss[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(3): 222-225,234.

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Correlation between telomere length of peripheral blood leukocytes and noise-induced hearing loss

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