肝癌组织中MPDZ基因拷贝数和表达变化及其诊断预后价值分析

doi:10.3969/j.issn.1004-616x.2017.03.001

Abstract

Abstract: OBJECTIVE:This study aimed to explore the copy number variations and expression of MPDZ and to evaluate their relationship with prognostic outcomes in liver cancer. METHODS:Copy number variations and expression of MPDZ were performed from TCGA database,and their relationships were analyzed. Expression of MPDZ in liver carcinoma (282 cases) and adjacent normal tissues (50 cases) were also performed,then the relationship between MPDZ expression and clinical pathological parameters,and its prognostic value were evaluated by statistical analysis. RESULTS:Copy number deletion (31.44%) was the most frequent copy number variations observed and it was associated with the expression of MPDZ. The expression was significantly lower than that in adjacent normal tissues (P < 0.05). Kaplan-Meier survival curves showed that patients with low MPDZ expression had significantly shorter overall survival time than those with higher MPDZ expression (Log-rank=12.48,P < 0.05). Receiver operating characteristic curve (ROC) showed that MPDZ gene expression was a sensitive and specific index of liver cancer diagnosis (AUC=0.86). CONCLUSION:MPDZ gene copy number deletion might be associated with the occurrence of liver cancer and the expression of MPDZ had some reference value for the diagnosis and prognosis of liver cancer.

Key words: MPDZgene, liver cancer, copy number variation, expression

CLC Number:

R730.2

HUANG Yongsheng, LIU Wenbin, HAN Fei, CUI Zhihong, AO Lin, CAO Jia, LIU Jinyi. MPDZ copy number variations, expression and prognostic value in liver cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(3): 161-165.

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MPDZ copy number variations, expression and prognostic value in liver cancer

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