DKK1在食管胃结合部腺癌患者血清中的水平及其临床诊断价值

doi:10.3969/j.issn.1004-616x.2017.02.013

Abstract

Abstract:

OBJECTIVE: To study the serum level and diagnostic value of Dickkopf-1(DKK1) in patients with adenocarcinoma at the esophago-gastric junction (AEGJ). METHODS: Serum levels of DKK1 in 79 patients with AEGJ and 101 normal controls were measured by enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristics (ROC) was used to calculate its diagnostic value. RESULTS: The serum levels of DKK1 were significantly higher in AEGJ than in normal controls (P=0.001). ROC curves showed that the optimum diagnostic cutoff for serum DKK1 was 2 615.9 pg/mL,providing an area under the curve (AUC) of 0.650 (95%CI:0.569-0.731),a sensitivity/specificity of 34.2%/95.0%. Moreover,serum DKK1 had early diagnostic value for AEGJ [AUC 0.674 (95%CI:0.521-0.827)],35.7% sensitivity and 96.0% specificity. Moreover,the positive rate of DKK1 was not significantly related to age,gender,size of tumor,depth of tumor invasion,lymph node status,or TNM stage (P > 0.05),but related to distant metastasis (P < 0.05). CONCLUSION: Serum levels of DKK1 was high in AEGJ patients which indicates that serum DKK1 may be a potential biomarker for early diagnosis of AEGJ.

Key words: DKK1, tumor marker, adenocarcinoma of esophago-gastric junction, diagnosis

CLC Number:

R730.4

XU Yiwei, GUO Hong, GUO Haipeng, PENG Yuhui. Serum level and clinical diagnostic value of DKK1 in adenocarcinoma at the esophago-gastric junction[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(2): 139-142.

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Serum level and clinical diagnostic value of DKK1 in adenocarcinoma at the esophago-gastric junction

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