长链非编码RNA XIST和miR-101-3p在子宫颈癌组织中的表达及关系

doi:10.3969/j.issn.1004-616x.2017.02.009

Abstract

Abstract:

OBJECTIVE: To investigate the expression and clinical significance of long non-coding RNA (LncRNA) XIST and miR-101-3p in cervical cancer. METHODS: Cervical cancer tissues and matched non-tumor para-neoplastic tissues were collected from 58 patients. Quantitative real-time PCR was used to examine the expression of LncRNA XIST and miR-101-3p,the correlation between them and their correlation with clinicopathological features were analyzed. RESULTS: LncRNA XIST expression was significantly up-regulated in cervical cancer tissues than in adjacent non-tumor tissues (P < 0.05). The expression of miR-101-3p was significantly down-regulated in cervical cancer tissues as compared with the adjacent tissues (P < 0.05).The expression of them in nucleic acid levels were negatively correlated(r=-0.68,P=0.000) and correlated significantly with FIGO stage,lymph node metastasis,and tissue size of tumor (P < 0.05). CONCLUSION: Our findings indicate that LncRNA XIST and miR-101-3p may be potential prognostic markers and therapeutic targets for cervical cancer. The expression of LncRNA XIST and miR-101-3p was negatively correlated.

Key words: cervical cancer, LncRNA XIST, miR-101-3p, lymphnode metastasis

CLC Number:

R737.33

LIU Ping. Expression of LncRNA XIST and miR-101-3p in cervical cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(2): 121-124.

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Expression of LncRNA XIST and miR-101-3p in cervical cancer

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