Carcinogenesis, Teratogenesis & Mutagenesis ›› 2017, Vol. 29 ›› Issue (2): 115-120.doi: 10.3969/j.issn.1004-616x.2017.02.008

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HLA-DRB1 and DPA1 gene polymorphisms in Hodgkin's lymphoma of Uighurs

ZHANG Haiyan, LI Xun   

  1. Breast Medicine, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang, China
  • Received:2016-11-23 Revised:2017-02-22 Online:2017-03-31 Published:2017-03-31

Abstract:

OBJECTIVE: To explore the relationship between the human leukocyte antigen (HLA) DRB1,DPA1 low resolution type alleles and susceptibility of Uighurs to develop Hodgkin's lymphomas (HL). METHODS: Using a case-control study design,DNA direct sequencing classification method (SBT) was used to detect alleles in HLA-DRB1 and expression of HLA-DPA1 gene among 40 cases of Uighur patients and 80 healthy controls. The HLA-DRB1 and DPA1 allele frequencies between the two groups were compared. The correlation between them with the pathogenesis of HL was analyzed. RESULTS: HLA-DRB1 and DPA1 low resolution alleles were detected 12,3 types in the case group and 13,4 types in the control group,the frequency distribution of which met the Hardy-Weninberg genetic balance test (P > 0.05). The results show that HLA-DRB1*15,DPA1*03 and DPA1*02-DRB1*13 gene frequencies were significantly more frequent in the Uighur patients than the controls (P=0.016,OR=3.476;P=0.002,OR=4.248;P=0.037,OR=3.028,respectively);HLA-DRB1*07 gene frequencies between the two groups were statistically significant (P=0.025,OR=0.314). CONCLUSION: HLA-DRB1,DPA1 gene polymorphism may be closely associated with the onset of HL among Uighurs and with pathogenesis of HL.

Key words: Hodgkin's lymphoma, Uygur, human leukocyte antigen, gene frequency

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