锶在兔体内部分组织器官分布与富集规律的模拟研究

doi:10.3969/j.issn.1004-616x.2017.02.007

Abstract

Abstract:

OBJECTIVE: We used the Japanese big-ear rabbits to study the distribution and accumulation of strontium in their different organs. METHODS: 24 Japanese big-ear rabbits were randomly allocated into one blank group and five experimental groups. Rabbits of the blank group (group 1) were fed with deionized water while the experimental group were fed with deionized water plus the addition of strontium chloride hexahydrate every other day. The concentration of strontium chloride was 0.002 g/mL. The volume of water with strontium that was given to the rabbits from groups 2 to 6 were 1,2,3,4 and 5 mL respectively. After 30 days of oral treatment,samples of blood,liver and back leg tibialis were taken. All samples were dried,mashed and decompounded by nitric acid. The concentration of strontium was analyzed by inductively coupled plasma atomic emission spectrometry (ICP-AES). RESULTS: Plasma strontium concentrations in rabbits positively related to oral treatment dose with strontium chloride. R2 of linear fitting method was 0.82. Liver strontium concentrations in rabbits showed no significant correlation with oral treatment dose. Back leg tibialis strontium concentrations in rabbits positively related to oral treatment dose with strontium chloride. R2 of linear fitting method was 0.98. Plasma strontium concentrations positively related to back leg tibialis strontium concentrations. R2 of linear fitting method was 0.76. CONCLUSION: Strontium was absorbed by the body from the gut,transferred through plasma and concentrated in bone.

Key words: strontium, bone, plasma, Japanese big-ear rabbit, concentration

CLC Number:

R811.5

HE Yingxue, YAN Dong, DING Kuke, JIANG Xiaoyan. Simulation study on the distribution and accumulation of strontium in some organs of rabbits[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(2): 111-114.

References

[1] 陆庆桃,梁琥琪,黄良余. 金属锶的应用和制取[J]. 上海有色金属,1990(1):1-7.

[2] 同珊. 金属锶及其化合物的应用[J]. 化学世界,1996(10):559-559.

[3] 陈锦芳,刘广山. 环境样品中90Sr的分析方法及其在海洋学研究中的应用[J]. 应用海洋学学报,2003,22(3):395-406.

[4] FORSBERG S,ROSÉN K,FERNANDEZ V,et al. Migration of ¹³⁷Cs and ⁹⁰Sr in undisturbed soil profiles under controlled and close-to-real conditions[J]. J Environ Radioact,50(3):235-252.

[5] SCHULERT A R,HODGES E J,LENHOFF E S,et al. Strontium-90 distribution in the human skeleton[J]. Health Phys,1959,2(1):62-68.

[6] WANG C J,WANG J J,CHIHYU C,et al. Transfer factors of ⁹⁰Sr and ¹³⁷Cs from soil to the sweet potato collected in Taiwan[J]. J Environ Radioact,2000,47(1):15-27.

[7] 姜晓燕,刘淑娟,何映雪,等. 菠菜和小白菜对核素锶的吸附与富集作用[J]. 癌变·畸变·突变,2015,27(6):463-466.

[8] STOUTJESDIJK J F,DESMET G M,PENNDERS R M J,et al. The determination of soil plant transfer factors of Mn-54,Co-60,Zn-65,Sr-90 and Cs-137 under natural circumstances[A]. Comm Eur Commun,1983,329-352.

[9] 中国环境监测总站. 中国土壤元素背景值[M]. 北京:中国环境科学出版社,1990.

[10] 敖嘉,唐运来,陈梅,等. Sr胁迫对油菜幼苗抗氧化指标影响的研究[J]. 核农学报,2010,24(1):166-170.

[11] 刘淑娟,闫冬,何映雪,等. 三种蔬菜对土壤中Sr元素富集和转移特性的研究[J]. 中华放射医学与防护杂志,2015,35(5):376-379.

[12] ROUSSELETF. 26 Week oral (gavage) toxicity study in the monkey:Calcium andstrontium determination[R]. IRIS Report,1992,TO-12911-026-FRA/501.

[13] ROUSSELETF. 26 Week oral gavage chronic toxicity study in the rat:Urine and serum determination of calcium and strontium[R]. IRIS Report,1992,TO-12911-025-FRA/501.

[14] PORS N S. The biological role of strontium[J]. Bone,2004,35(3):583.

[15] BONNEVIER J,MALMQVIST U,SONNTAG D,et al. Sustained norepinephrine contraction in the rat portal vein is lost when Ca²⁺ is replaced with Sr²⁺[J]. Ajp Cell Physiol,2002,282(4):845-852.

[16] MEUNIER P J. Study of the dose-effect relationship of S12911 in the normal growing rat[R]. IRIS Report,1990,PHN-12911-004-F/2.

[17] ALLAIN P. 26 Week oral (gavage) toxicity study in the monkey:Bone calcium and strontium content[R]. IRIS Report,1994. TO-12911-026-FRA/502.

Simulation study on the distribution and accumulation of strontium in some organs of rabbits

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	YANG Liyan, LIU Zou, HAO Jiajie, ZHANG Yu, WANG Mingrong. Study on the mechanism of nucleo-plasma translocation of p62 protein in esophageal squamous cell carcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 338-344.
[2]	JIANG Xiaoyan, LIU Shujuan, YAN Dong, HE Yingxue, DING Kuke. Study on accumulation and migration of strontium in pepper [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(4): 309-311,316.
[3]	ZHOU Su, LI Rui, ZHU Hongyan, ZHANG Zhichao, FANG Jing, TANG Liming. An optical density method for determining bacterial concentrations in the Salmonella typhimurium reverse mutation assay [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(1): 62-66.
[4]	YAN Dong, DING Kuke, HE Yingxue, FAN Li, JIANG Xiaoyan. Accumulation and migration of strontium in three plants under hydroponic culture [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(1): 64-68.
[5]	DU Juan, HU Xiangyang, LIU Dan, HU Wei, CHEN Tao. Inhibitory effect of total alkaloids of Tougucao on bone metastasis of breast cancer cells in mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(6): 435-441.
[6]	LIU Dan, ZHANG Wen, WANG Xinyi, CHEN Tao, HU Wei. Treatment of Cionbufagin on analgesic effect and activation of glial cells in the spinal cord of cancer-induced bone pain rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(4): 302-306.
[7]	JIA Lixia, ZHANG Qi, HOU Xiaohong, MENG Qinghe, HUANG Yao, ZHOU Wenjuan, HAO Weidong. Effects of chlorocholine chloride on expression of skeletal development-related genes and proteins in MC3T3-E1 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(3): 188-193,199.
[8]	LIU Fang, WANG Zhuanzi, WEI Wei, LI Wenjian, DANG Bingrong. Total body irradiation of mice with carbon-ion caused damage to the hematopoietic system [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 109-113,119.
[9]	JIANG Xiaoyan, LI Yifeng, YAN Dong, HE Yingxue, DING Kuke. Effect of Paenibacillus polymyxa on strontium enrichment in rape [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(1): 58-61.
[10]	LIU Fuzhi, LI Hongtu, WU Chuancheng, CAI Ailan, CHEN Yu, LIU Baoying. A case control study on presence of chemical elements in plasma of gastric cancer patients [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(3): 230-234.
[11]	YUAN Ye, CHEN Dandan, JING Shufang, YU Yongsheng, CHEN Jianheng, WU Chunqi, SHI Chang. Mutagenic effects of N-(n-butyl)-thiophosphorictriamide in somatic and germ cells of mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(6): 432-437.
[12]	FU Bufang, WANG Li. Determination of residual organic solvents in allogeneic bones [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 314-316,331.
[13]	LI Yifeng, YAN Dong, HE Yingxue, JIANG Xiaoyan, DING Kuke. Some physiological effects of strontium on hydroponic Chinese cabbage and rape [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(3): 223-226.
[14]	JIANG Xiaoyan, LIU Shujuan, HE Yingxue, YAN Dong, GAO Ling, LI Yifeng, DING Kuke. Spinach and Chinese cabbage on the uptake and accumulation of strontium [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(6): 463-466.
[15]	GUO Xia，JIN Hua，Mayila·KAMILIJIANG，LIU Kai-jiang，Axiangu·HASIMU,Halidan·REYIMU，WU Gui-zhen，Abulizi·ABUDULA. Correlation of the dynamic changes of plasma apoA l content and mTOR activity with cervical carcinogenesis development in Uyghur women [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2014, 26(3): 185-192.