贲门腺癌中Sox17蛋白表达及其与β-catenin、cyclin D1蛋白相关性研究

doi:10.3969/j.issn.1004-616x.2017.02.006

Abstract

Abstract:

OBJECTIVE: To investigate expression of Sox17,β-catenin and cyclin D1 proteins in gastric cardia adenocarcinoma(GCA),and to establish their relationship with pathogenesis of GCA. METHODS: Immunohistochemistry method was applied to examine the expression of Sox17,β-catenin and cyclin D1 proteins in 78 samples of GCA and the corresponding adjacent non-cancerous tissues．RESULTS: In GCA tissues,the frequency of Sox17,β-catenin and cyclin D1 expression was 47.4% (37/78),83.3% (65/78) and 70.5%(55/78),respectively,which was significantly lower than that in corresponding adjacent non-cancerous tissues:69.2%(54/78),62.8%(49/78) and 44.9%(35/78),(P < 0.01). The frequency of β-catenin ectopic expression was 83.3%(65/78) in GCA tissues which was significantly higher than that in corresponding adjacent non-cancerous tissues of 62.8%(49/78) (P < 0.01). Sox17 expression was negatively correlated with ectopic expression of β-catenin and cyclin D1 (r=-0.264,P < 0.05;r=-0.287,P < 0.05). Sox17 were significantly correlated with tumor stage (P=0.045). β-catenin and cyclin D1 were significantly correlated with lymph node metastasis(P < 0.05). CONCLUSION: Low level expression of Sox17 protein may play an important role in the development of GCA via aberrantly activating the canonical Wnt/ β-catenin signaling pathway through influencing the expression of β-catenin and cyclin D1.

Key words: Sox17, β-catenin, cyclin D1, Wnt signal pathway, gastric cardia adenocarcinoma

CLC Number:

R735.2

PAN Pan, KUANG Gang, GUO Yanli, GUO Wei, DONG Zhiming, YANG Fei. Expression of Sox17 protein and correlation with β-catenin and cyclin D1 protein in gastric cardia adenocarcinoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(2): 106-110,120.

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Expression of Sox17 protein and correlation with β-catenin and cyclin D1 protein in gastric cardia adenocarcinoma

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