Syntenin在非小细胞肺癌中的表达及其与患者总生存期的关系

doi:10.3969/j.issn.1004-616x.2017.02.005

Abstract

Abstract:

OBJECTIVE: The aim of this study was to detect the expression of Syntenin in non-small cell lung cancer (NSCLC) tissues and to explore its clinical significance. METHODS: We detected expression of Syntenin in 147 NSCLC tissues and 147 para-carcinoma tissues by tissue microarray and immunohistochemical staining method,and analyzed the relationship of Syntenin expression with clinicopathological parameters and prognosis of NSCLC patients. RESULTS: Expression level of Syntenin (positive rate 49.7%) in NSCLC tissues was significantly higher than that in adjacent lung tissues (positive rate 4.1%,P < 0.01). Over-expression of Syntenin was associated with lymph node metastasis,clinical stage and pathological type in NSCLC patients (P=0.039,P=0.038 and P=0.024),but not with age or gender. The Kaplan-Meier survival analysis revealed that Syntenin expression in primary tumors was significantly associated with patients' overall survival (P=0.028). CONCLUSION: Syntenin protein was over-expressed in NSCLC tissues,and was associated with poor prognosis of patients.

Key words: Syntenin, non-small cell lung cancer, lymph node metastasis, overall survival

CLC Number:

R730.2

SONG Jie, LI Ping, YU Xuexin, FENG Lin, GAO Yanning, XIAO Ting. Expression of Syntenin in non-small cell lung cancer tissues and its relationship with overall survival of patients[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(2): 102-105.

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Expression of Syntenin in non-small cell lung cancer tissues and its relationship with overall survival of patients

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