结直肠癌组织中KIAA1522的表达及临床意义

doi:10.3969/j.issn.1004-616x.2017.02.002

Abstract

Abstract:

OBJECTIVE: To investigate expression status of KIAA1522 in colorectal cancer (CRC),and its correlation with clinicopathological features and prognosis. METHODS: Expression of KIAA1522 protein was determined with tissue microarrays-immunohistochemistry (TMA-IHC) technique in surgically-resected colorectal cancer tissues and adjacent normal epithelia from 96 patients. The relationship between KIAA1522 expression and clinicopathological characteristics and prognosis of the patients were analyzed. RESULTS: KIAA1522 protein was mainly localized in the cytoplasm of colorectal epithelial cells. While only 12.5% (12/96) of normal colorectal epithelia displayed positive staining,81.3% (78/96) of CRC specimens showed over-expression of KIAA1522. The difference between them was highly significant (P < 0.001). Kaplan-Meier survival analysis revealed that high level of KIAA1522 expression was correlated with lower 3-year disease free survival (DFS) rate of CRC patients (P=0.017). Further more,KIAA1522 up-regulation was significantly correlated with distant metastasis (P=0.012). More importantly,Cox regression analysis indicated that KIAA1522 protein expression was an independent prognosis factor in CRC (P=0.020). CONCLUSION: KIAA1522 was frequently up-regulated in CRC,and its over-expression was significantly correlated with distant metastasis and poor prognostic,thus KIAA1522 over-expression may served as a new prognostic marker in colorectal cancer.

Key words: colorectal cancer, KIAA1522, metastasis, prognosis

CLC Number:

R730.2

LIU Tingting, LIANG Jianwei, YU Jing, CHANG Chen, HAO Jiajie, CAI Yan, ZHOU Zhixiang, WANG Mingrong, ZHANG Tongtong, ZHANG Yu. Significance in expression of KIAA1522 in colorectal cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(2): 87-90,95.

References

[1] SIEGEL R L,MILLER K D,JEMAL A. Cancer statistics,2016[J]. CA Cancer J Clin,2016,66(1):7-30.

[2] CHEN W,ZHENG R,BAADE P D,et al. Cancer statistics in China,2015[J]. CA Cancer J Clin,2016,66(2):115-132.

[3] HANAHAN D,WEINBERG R A. Hallmarks of cancer:the next generation[J]. Cell,2011,144(5):646-674.

[4] CARETHERS J M,JUNG B H. Genetics and genetic biomarkers in sporadic colorectal cancer[J]. Gastroenterology,2015,149(5):1177-1190.

[5] FREEMAN H J. Early stage colon cancer[J]. World J Gastroenterol,2013,19(46):8468-8473.

[6] OKAZAKI N K R,OHARA R. Prediction of the coding sequences of mouse homologues of KIAA gene:IV. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries[J]. DNA Res,2004,(11):205-208.

[7] 段丽琼. KIAA基因家族的研究进展[J]. 上海第二医科大学学报,2005,(4):337-340.

[8] LIU Y Z,YANG H,CAO J,et al. KIAA1522 is a novel prognostic biomarker in patients with non-small cell lung cancer [J]. Sci Rep,2016,6:24786.

[9] ZHANG T T,JIANG Y Y,SHANG L,et al. Overexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERK-dependent signaling pathway[J]. Mol Carcinog,2015,54(10):1205-1213.

[10] 吴李飞. UHRF1蛋白在结直肠癌中的表达情况及其预后判断价值[J]. 癌变·畸变·突变,2015,27(1):30-34.

[11] 张彤彤. Cortactin蛋白在结直肠癌中的表达变化及其临床意义[J]. 癌变·畸变·突变,2014,26(1):20-23.

[12] PANAGIOTOPOULOU I G,PARASHAR D,QASEM E,et al. Neoadjuvant long-course chemoradiotherapy for rectal cancer:Does time to surgery matter?[J]. Int Surg,2015,100(6):968-973.

[13] CHEN Y,YIN D,LI L,et al. Screening aberrant methylation profile in esophageal squamous cell carcinoma for Kazakhs in Xinjiang area of China[J]. Mol Biol Rep,2015,42(2):457-464.

[14] COPPEDE F. Epigenetic biomarkers of colorectal cancer:Focus on DNA methylation[J]. Cancer Lett,2014,342(2):238-247.

[15] AGELOPOULOS K,RICHTER G H,SCHMIDT E,et al. Deep sequencing in conjunction with expression and functional analyses reveals activation of FGFR1 in Ewing sarcoma[J]. Clin Cancer Res,2015,21(21):4935-4946.

[16] LIU Y Z,JIANG Y Y,WANG B S,et al. A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens[J]. Cancer Cytopathol,2014,122(11):833-841.

Significance in expression of KIAA1522 in colorectal cancer

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	PENG Youbin, LIN Hao, LI Ming, HUANG Haihua. Expression of TPX2 and its clinicalsignificance in non-muscle-invasive bladder cancer [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 30-34.
[2]	GUO Zhaomeng, ZHANG Hua, ZHANG Peng. Mechanisms of Orai1 on invasion and epithelial-mesenchymal transformation in nasopharyngeal carcinoma cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 420-425.
[3]	JIAO Wenpeng, HOU Lin, CUI Meijuan, JIAO Wenjing, MA Ming, ZHANG Jinyan. Expression of miR-93-5p and miR-106b-5p in alcohol-related liver cancer and its clinical significance [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 430-434.
[4]	GAO Xiaobin, WU Xueliang, WANG Shengjie, SUN Guangyuan, WANG Wenjing, LIANG Feng, ZHAO Yifeng, LIU Zhenxian, ZHANG Yingchun. Expression of TRIM59 and its correlations with clinicopathological features in colorectal cancers [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 446-450.
[5]	JIAO Wenjing, ZHANG Jinyan, MA Ming, GUO Xiujuan, FENG Junhua, SHAO Junguo, JIAO Wenpeng. Expression and clinical significance of MTDH and FoxM1 in hepatocellular carcinomas [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 349-353,359.
[6]	ZHANG Shimin, ZHAO Ruijun. Expression of protein tyrosine phosphatase receptor J in breast cancer tissues and its relationship with clinical prognosis [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(4): 276-279,285.
[7]	LIU Xiaoxia, LI Weixia, LI Zhijia, SU Zhenjun, DUAN Xiaohui, HAN Weiwen, WANG Yunxiao, HE Xiaolei, Lu Linlin, JIA Jinhai. Correlations between glutathione peroxidase in serum and clinicopathological outcomes of advanced non-small cell lung cancer [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(4): 286-290,295.
[8]	LI Bo, LI Gairui, ZHAO Wei, PENG Xiaolin, ZHAO Dan, PENG Ji. Evaluation of sample preservation solution for fecal DNA detection [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(4): 312-316.
[9]	LUO Jiao, ZHANG Kunchi, ZHOU Li. Analysis of differentially expressed microRNAs between the triple negative breast cancer cell line MDA-MB-231 and its brain metastasis cell line [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(3): 218-224.
[10]	ZHANG Yuling, WU Jundong, PANG Dongyue, CHEN Chunfa. Changes of Ki67 expression before and after neoadjuvant chemotherapy as a predictor for therapeutic response and rognosis in breast cancers [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(3): 230-235,245.
[11]	SHI Hailin, HE Tianji, LIU Feng, CAI Menghui, GE Bo. Prognostic value of TCGA-database mutation burden in muscle-invasive bladder cancers [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 430-437,443.
[12]	DING Yawen, JIAO Wenjing, WANG Pengyu, LU Gang, MA Ming. Immunophenotype characteristics of plasma cells and clinical significance in multiple myeloma patients [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 464-468,489.
[13]	YANG Xiuyuan, PAN Yuelong. Expression of CD10 protein in colorectal carcinomas and its clinical significance [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 344-349.
[14]	SHAO Junguo, JIAO Wenjing, WANG Xuexiao, ZHANG Jinyan, MA Ming. Clinical significance of mi-429 and Bmi-1 mRNA expressions in lung carcinoma tissues [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 369-373.
[15]	Lü Yanping, WU Chuancheng, YANG Shuangfeng, HE Chenzhou, HAN Renjie, YAN Wei, LIU Baoying. Relationship between differentially expressed miRNA-SNPs and prognosis of gastric cancer [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 380-386.