[1] Brewster A,Helzlsouer K. Breast cancer epidemiology,prevention, and early detection[J]. Curr Opin Oncol,2001,13(6):420-425.
[2] Hall JM,Lee MK,Newman B,et al. Linkage of early-onset familial breast cancer to chromosome 17q21[J]. Science,1990,250(4988): 1684-1689.
[3] Monteiro AN,August A,Hanafusa H. Evidence for a transcriptional activation function of BRCA1 C-terminal region[J]. Proc Natl Acad Sci USA,1996,93(24):13595-13599.
[4] Al-Ejeh F,Kumar R,Wiegmans A,et al. Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes[J]. Oncogene,2010,29(46):6085-6098.
[5] Hoeijmakers JH. DNA damage,aging,and cancer[J]. N Engl J Med, 2009,361(15):1475-1485.
[6] Bernstein C,Bernstein H,Payne CM,et al. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways:fail-safe protection against carcinogenesis[J]. Mutat Res,2002,511(2): 145-178.
[7] Shrivastav M,De Haro LP,Nickoloff JA. Regulation of DNA double-strand break repair pathway choice[J]. Cell Res,2008,18(1):134-147.
[8] Yang J,Yu Y,Hamrick HE,et al. ATM,ATR and DNA-PK:initiators of the cellular genotoxic stress responses[J]. Carcinogenesis,2003,24(10):1571-1580.
[9] Jackson SP,Bartek J. The DNA-damage response in human biology and disease[J]. Nature,2009,461(7267):1071-1078.
[10] Stracker TH,Petrini JH. The MRE11 complex:starting from the ends[J]. Nat Rev Mol Cell Biol,2011,12(2):90-103.
[11] Marechal A,Zou L. DNA damage sensing by the ATM and ATR kinases[J]. Cold Spring Harb Perspect Biol,2013,5(9):a012716.
[12] Ljungman M. The DNA damage response-repair or despair?[J]. Environ Mol Mutagen,2010,51(8/9):879-889.
[13] Schreiber V,Dantzer F,Ame JC,et al. Poly(ADP-ribose):novel functions for an old molecule[J]. Nat Rev Mol Cell Biol,2006,7(7): 517-528.
[14] Moldovan GL,D'Andrea AD. How the fanconi anemia pathway guards the genome[J]. Annu Rev Genet,2009,43:223-249.
[15] Khanna KK,Jackson SP. DNA double-strand breaks:signaling,repair and the cancer connection[J]. Nat Genet,2001,27(3):247-254.
[16] Burma S,Chen BP,Chen DJ. Role of non-homologous end joining (NHEJ) in maintaining genomic integrity[J]. DNA Repair (Amst), 2006,5(9/10):1042-1048.
[17] Goodarzi AA,Jeggo PA. The repair and signaling responses to DNA double-strand breaks[J]. Adv Genet,2013,82:1-45.
[18] Davis AJ,Chen DJ. DNA double strand break repair via non-homologous end-joining[J]. Transl Cancer Res,2013,2(3):130-143.
[19] Shibata A,Conrad S,Birraux J,et al. Factors determining DNA double-strand break repair pathway choice in G2 phase[J]. EMBO J,2011,30(6):1079-1092.
[20] Sartori AA,Lukas C,Coates J,et al. Human CtIP promotes DNA end resection[J]. Nature,2007,450(7169):509-514.
[21] Nimonkar AV,Genschel J,Kinoshita E,et al. BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair[J]. Genes Dev,2011, 25(4):350-362.
[22] Huertas P. DNA resection in eukaryotes:deciding how to fix the break[J]. Nat Struct Mol Biol,2010,17(1):11-16.
[23] Moynahan ME,Jasin M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis[J]. Nat Rev Mol Cell Biol,2010,11(3):196-207.
[24] Chapman JR,Taylor MR,Boulton SJ. Playing the end game:DNA double-strand break repair pathway choice[J]. Mol Cell,2012, 47(4):497-510.
[25] Durant ST,Nickoloff JA. Good timing in the cell cycle for precise DNA repair by BRCA1[J]. Cell Cycle,2005,4(9):1216-1222.
[26] Bau DT,Mau YC,Shen CY. The role of BRCA1 in non-homologous end-joining[J]. Cancer Lett,2006,240(1):1-8.
[27] Yang ES,Xia F. BRCA116 years later:DNA damage-induced BRCA1 shuttling[J]. FEBS J,2010,277(15):3079-3085.
[28] Jiang G,Plo I,Wang T,et al. BRCA1-Ku80 protein interaction enhances end-joining fidelity of chromosomal double-strand breaks in the G1 phase of the cell cycle[J]. J Biol Chem,2013,288(13):8966-8976.
[29] Wang H,Zeng ZC,Bui TA,et al. Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2[J]. Cancer Res,2001, 61(1):270-277.
[30] Bunting SF,Callen E,Wong N,et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks[J]. Cell,2010,141(2):243-254.
[31] Escribano-Diaz C,Orthwein A,Fradet-Turcotte A,et al. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice[J]. Mol Cell,2013, 49(5):872-883.
[32] Davis AJ,Chi L,So S,et al. BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle[J]. Nucleic Acids Res,2014,42(18):11487-11501.
[33] Saha J,Davis AJ. Unsolved mystery:the role of BRCA1 in DNA end-joining[J]. J Radiat Res,2016,57 Suppl 1:i18-i24
[34] Moynahan ME,Chiu JW,Koller BH,et al. BRCA1 controls homology-directed DNA repair[J]. Mol Cell,1999,4(4):511-518.
[35] Huen MS,Sy SM,Chen J. BRCA1 and its toolbox for the maintenance of genome integrity[J]. Nat Rev Mol Cell Biol,2010,11(2):138-148.
[36] Yu X,Chen J. DNA damage-induced cell cycle checkpoint control requires CtIP,a phosphorylation-dependent binding partner of BRCA1 C-terminal domains[J]. Mol Cell Biol,2004,24(21):9478-9486.
[37] Chen L,Nievera CJ,Lee AY,et al. Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair[J]. J Biol Chem,2008,283(12):7713-7720.
[38] Wang H,Shao Z,Shi LZ,et al. CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks[J]. J Biol Chem,2012,287(25):21471-21480.
[39] Scully R,Chen J,Plug A,et al. Association of BRCA1 with Rad51 in 综述mitotic and meiotic cells[J]. Cell,1997,88(2):265-275.
[40] Garcia-Higuera I,Taniguchi T,Ganesan S,et al. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway[J]. Mol Cell,2001,7(2):249-262.
[41] Bhattacharyya A,Ear US,Koller BH,et al. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin[J]. J Biol Chem,2000,275(31):23899-23903.
[42] Cantor SB,Andreassen PR. Assessing the link between BACH1 and BRCA1 in the FA pathway[J]. Cell Cycle,2006,5(2):164-167.
[43] Joukov V,Chen J,Fox EA,et al. Functional communication between endogenous BRCA1 and its partner,BARD1,during Xenopus laevis development[J]. Proc Natl Acad Sci USA,2001,98(21):12078-12083.
[44] Ayi TC,Tsan JT,Hwang LY,et al. Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein[J]. Oncogene,1998,17(16):2143-2148.
[45] Yu X,Chini CC,He M,et al. The BRCT domain is a phospho-protein binding domain[J]. Science,2003,302(5645):639-642.
[46] Morris JR,Solomon E. BRCA1:BARD1 induces the formation of conjugated ubiquitin structures,dependent on K6 of ubiquitin,in cells during DNA replication and repair[J]. Hum Mol Genet,2004,13(8): 807-817.
[47] Kim H,Huang J,Chen J. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response[J]. Nat Struct Mol Biol,2007,14(8):710-715.
[48] Wang B,Matsuoka S,Ballif BA,et al. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response[J]. Science,2007,316(5828):1194-1198.
[49] Kim H,Chen J,Yu X. Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response[J]. Science,2007,316(5828):1202-1205.
[50] Coleman KA,Greenberg RA. The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection[J]. J Biol Chem,2011,286(15):13669-13680.
[51] Xia B,Sheng Q,Nakanishi K,et al. Control of BRCA2 cellular and clinical functions by a nuclear partner,PALB2[J]. Mol Cell,2006, 22(6):719-729.
[52] Sy SM,Huen MS,Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair[J]. Proc Natl Acad Sci USA,2009,106(17):7155-7160.
[53] Cantor SB,Bell DW,Ganesan S,et al. BACH1,a novel helicase-like protein,interacts directly with BRCA1 and contributes to its DNA repair function[J]. Cell,2001,105(1):149-160.
[54] Shiozaki EN,Gu L,Yan N,et al. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide:implications for signaling[J]. Mol Cell,2004,14(3):405-412.
[55] Baumann P,Benson FE,West SC. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro[J]. Cell,1996,87(4):757-766.
[56] Zhang H,Liu H,Chen Y,et al. A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice[J]. Nat Commun,2016,7:10201. |
