茶树槲寄生“螃蟹脚”水提物的急性毒性和遗传毒性

doi:10.3969/j.issn.1004-616x.2016.04.012

Abstract

Abstract: OBJECTIVE: To investigate the acute toxicity and genotoxicity of crude water extracts from tea mistletoe (CWE). METHODS: The following assays were used for the investigation:Ames assay, acute toxicity in rats, micronuclei of mouse bone marrow polychromatic erythrocytes, and mouse spermatogonium chromosome aberrations. RESULTS: Oral acute toxicity test revealed that the LD₅₀ of CWE was approximate 21.5 g/kg in rats, thus CWE was relatively non-toxic. No mutagenic activities were detected in the Salmonella typhimurium reverse mutation assay (Ames test), both with and without metabolic activation. In addition, CWE demonstrated no positive adverse effects in the in vivo micronucleus test or spermatogonium chromosome aberration test of ICR mice. CONCLUSION: Under our experimental conditions, water extracts from CWE showed no evidence of acute toxicity and no positive evidence of genotoxicity.

Key words: tea mistletoe, acute toxicity test, Ames test, micronucleus test, chromosome aberration test

CLC Number:

R114

YING Jian, HAO Binxiu, MENG Qingjia, CHEN Ran, WANG Liming, WANG Chunling. Acute toxicity and genotoxicity of crude water extracts from tea mistletoe Viscum Liquidambaricolum Hayata[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 306-309,324.

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Acute toxicity and genotoxicity of crude water extracts from tea mistletoe Viscum Liquidambaricolum Hayata

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