XPD基因751位点单核苷酸多态与肺癌遗传易感性关联的Meta分析

doi:10.3969/j.issn.1004-616x.2016.04.009

Abstract

Abstract: OBJECTIVE: Reports on association between the xeroderma pigmentosum group D (XPD) and genetic susceptibility to lung cancer have not been consistent. Therefore, we have conducted a Meta analysis to review the association. METHODS: The databases of PubMed, CNKI, cqVIP or wanfang were retrieved to search for publications about case-control studies which were published from 2000-2014. The focus was on XPD 751 polymorphisms and genetic susceptibility to lung cancer. Relevant data were extracted from the selected publications. Corresponding combination methods were used and the pooled relative risk (OR) and its 95% confidence interval (95%CI) were calculated after the heterogeneity test with the statistical analysis software RevMan 4.2. Meanwhile, Funnel Plots were protracted to estimate the effect of publication bias. RESULTS: The study included 28 domestic and international reports with 9 012 cumulative subjects of case group and 10 542 controls. For the Lys/Gln versus the Lys/Lys variant groups, the OR was 1.18, the 95%CI was 1.07-1.31, and P=0.001 which reflected on random effect model. For the Gln/Gln versus the Lys/Lys variant groups, the OR was 1.28, the 95%CI was 1.14-1.44, and P=0.01, which reflected on fixed effect model. Subgroup analyses revealed that XPD 751 polymorphism was associated with genetic susceptibility to lung cancer. CONCLUSION: For individuals carrying the codon 751 Gln/Lys or Gln/Gln genotypes, the risk of lung cancer increased significantly.

Key words: xeroderma pigmentosum group D, single nucleotide polymorphisms, lung cancer, Lys751Gln, Meta-analysis

CLC Number:

R73-31

XIAO Sha, ZHAO Xiujuan, KUANG Shicheng, LIU Yunru, LONG Wenfang, YANG Jianjun, HUANG Hairong. A Meta-analysis of the relationship between XPD 751 gene polymorphism and lung cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 292-297.

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A Meta-analysis of the relationship between XPD 751 gene polymorphism and lung cancer

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