PFTK1在人非小细胞肺癌中的表达及临床意义

doi:10.3969/j.issn.1004-616x.2016.03.015

Abstract

Abstract: OBJECTIVE:To investigate the expression of PFTAIRE protein kinase 1(PFTK1) in human non-small cell lung cancer (NSCLC) and to analyze its clinical significance. METHODS:Immunohistochemistry was used to detect the protein expression of PFTK1 in 119 cases of NSCLC. The sample rate was tested by chi-square test. Kaplan-Metier method was used to calculate survival rates and survival rates were tested by Log-Rank test. RESULTS:In NSCLC tissues, PFTK1 existed mainly in the cytoplasm and nucleus. In the 119 cases, PFTK1 expression was higher in cancer than in adjacent normal alveolar epithelium tissues, and the ratio was 63.9% (76/119). PFTK1 expression was significantly correlated with both different T (primary tumor) stage and lymph node metastasis (P<0.05), whereas it was not correlated with age, sex, clinical stage, pathological grade, pathology type, tumor size and N (regional lymph node)stage (P>0.05). In patients with lung squamous cell carcinoma, if stratification factor N stage was controlled, the survival analysis showed that when the expression level of PFTK1 was higher the overall survival time of patients was shorter(P<0.05). CONCLUSION:PFTK1 was overexpressed in NSCLC, was closely associated with T stage and lymph node metastasis, and affected prognosis of patients. PFTK1 may become a potential biomarker for NSCLC.

Key words: PFTAIRE protein kinase 1, non-small cell lung cancer, immunohistochemistry, survival time

CLC Number:

R734.2

ZHAI Xiaoran, JIANG Mei, ZHAO Xiaoting, GU Meng, YUE Wentao. Clinical significance of PFTK1 expression in human non-small cell lung cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(3): 231-235.

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Clinical significance of PFTK1 expression in human non-small cell lung cancer

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